HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this restriction. Here, we show that HIV-1 Vpu ind...

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Detalles Bibliográficos
Autores principales: Mangeat, Bastien, Gers-Huber, Gustavo, Lehmann, Martin, Zufferey, Madeleine, Luban, Jeremy, Piguet, Vincent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729927/
https://www.ncbi.nlm.nih.gov/pubmed/19730691
http://dx.doi.org/10.1371/journal.ppat.1000574

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