Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

The unfolded protein response (UPR) is an evolutionarily conserved mechanism to allow cells to adapt to stress targeting the endoplasmic reticulum (ER). Induction of ER chaperone GRP78/BiP increases protein folding capacity; as such it represents a major survival arm of UPR. Considering the central...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Min, Zhou, Hui, Wey, Shiuan, Baumeister, Peter, Lee, Amy S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729930/
https://www.ncbi.nlm.nih.gov/pubmed/19718440
http://dx.doi.org/10.1371/journal.pone.0006868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729930/
https://www.ncbi.nlm.nih.gov/pubmed/19718440
http://dx.doi.org/10.1371/journal.pone.0006868

Ejemplares similares