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Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture
INTRODUCTION: Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern sim...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729985/ https://www.ncbi.nlm.nih.gov/pubmed/18677494 http://dx.doi.org/10.1007/s00402-008-0707-6 |
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author | Akritopoulos, Panagiotis Papaioannidou, Paraskevi Hatzokos, Ippokratis Haritanti, Afroditi Iosifidou, Eirini Kotoula, Maria Mirtsou-Fidani, Vassiliki |
author_facet | Akritopoulos, Panagiotis Papaioannidou, Paraskevi Hatzokos, Ippokratis Haritanti, Afroditi Iosifidou, Eirini Kotoula, Maria Mirtsou-Fidani, Vassiliki |
author_sort | Akritopoulos, Panagiotis |
collection | PubMed |
description | INTRODUCTION: Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern similar to clinical treatment patterns, that is, in a high dose and for a short period after bone fracture. METHOD: Closed non-displaced mid-diaphyseal fractures in the middle of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intra-peritoneally every day for 7 days. In the control group, normal saline was administered intra-peritoneally every day for 7 days. In both groups fracture healing (bone union and callus formation) was evaluated with X-rays 28 and 42 days after surgery. RESULTS: Bone healing was lower in the study group (60 vs. 80% in the control group 28 days after fracture and 80 vs. 90% 42 days after fracture) but this difference was not statistically significant (P > 0.05). CONCLUSION: Parecoxib does not have a significant long-term effect on bone healing in rats, when it is administered in a high dose and for a short period after bone fracture. |
format | Text |
id | pubmed-2729985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-27299852009-08-24 Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture Akritopoulos, Panagiotis Papaioannidou, Paraskevi Hatzokos, Ippokratis Haritanti, Afroditi Iosifidou, Eirini Kotoula, Maria Mirtsou-Fidani, Vassiliki Arch Orthop Trauma Surg Basic Science INTRODUCTION: Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern similar to clinical treatment patterns, that is, in a high dose and for a short period after bone fracture. METHOD: Closed non-displaced mid-diaphyseal fractures in the middle of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intra-peritoneally every day for 7 days. In the control group, normal saline was administered intra-peritoneally every day for 7 days. In both groups fracture healing (bone union and callus formation) was evaluated with X-rays 28 and 42 days after surgery. RESULTS: Bone healing was lower in the study group (60 vs. 80% in the control group 28 days after fracture and 80 vs. 90% 42 days after fracture) but this difference was not statistically significant (P > 0.05). CONCLUSION: Parecoxib does not have a significant long-term effect on bone healing in rats, when it is administered in a high dose and for a short period after bone fracture. Springer-Verlag 2008-08-02 2009-10 /pmc/articles/PMC2729985/ /pubmed/18677494 http://dx.doi.org/10.1007/s00402-008-0707-6 Text en © The Author(s) 2008 |
spellingShingle | Basic Science Akritopoulos, Panagiotis Papaioannidou, Paraskevi Hatzokos, Ippokratis Haritanti, Afroditi Iosifidou, Eirini Kotoula, Maria Mirtsou-Fidani, Vassiliki Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title_full | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title_fullStr | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title_full_unstemmed | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title_short | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
title_sort | parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture |
topic | Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729985/ https://www.ncbi.nlm.nih.gov/pubmed/18677494 http://dx.doi.org/10.1007/s00402-008-0707-6 |
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