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Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis

BACKGROUND: There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examin...

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Autores principales: Villar, Jesús, Pérez-Méndez, Lina, Espinosa, Elena, Flores, Carlos, Blanco, Jesús, Muriel, Arturo, Basaldúa, Santiago, Muros, Mercedes, Blanch, Lluis, Artigas, Antonio, Kacmarek, Robert M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730016/
https://www.ncbi.nlm.nih.gov/pubmed/19718443
http://dx.doi.org/10.1371/journal.pone.0006818
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author Villar, Jesús
Pérez-Méndez, Lina
Espinosa, Elena
Flores, Carlos
Blanco, Jesús
Muriel, Arturo
Basaldúa, Santiago
Muros, Mercedes
Blanch, Lluis
Artigas, Antonio
Kacmarek, Robert M.
author_facet Villar, Jesús
Pérez-Méndez, Lina
Espinosa, Elena
Flores, Carlos
Blanco, Jesús
Muriel, Arturo
Basaldúa, Santiago
Muros, Mercedes
Blanch, Lluis
Artigas, Antonio
Kacmarek, Robert M.
author_sort Villar, Jesús
collection PubMed
description BACKGROUND: There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examined whether serial serum levels of LBP could be used as a marker of outcome. METHODOLOGY/PRINCIPAL FINDINGS: LBP serum levels at study entry, at 48 hours and at day-7 were measured in 180 patients with severe sepsis. Data regarding the nature of infections, disease severity, development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), and intensive care unit (ICU) outcome were recorded. LBP serum levels were similar in survivors and non-survivors at study entry (117.4±75.7 µg/mL vs. 129.8±71.3 µg/mL, P = 0.249) but there were significant differences at 48 hours (77.2±57.0 vs. 121.2±73.4 µg/mL, P<0.0001) and at day-7 (64.7±45.8 vs. 89.7±61.1 µg/ml, p = 0.017). At 48 hours, LBP levels were significantly higher in ARDS patients than in ALI patients (112.5±71.8 µg/ml vs. 76.6±55.9 µg/ml, P = 0.0001). An increase of LBP levels at 48 hours was associated with higher mortality (odds ratio 3.97; 95%CI: 1.84–8.56; P<0.001). CONCLUSIONS/SIGNIFICANCE: Serial LBP serum measurements may offer a clinically useful biomarker for identification of patients with severe sepsis having the worst outcomes and the highest probability of developing sepsis-induced ARDS.
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spelling pubmed-27300162009-08-31 Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis Villar, Jesús Pérez-Méndez, Lina Espinosa, Elena Flores, Carlos Blanco, Jesús Muriel, Arturo Basaldúa, Santiago Muros, Mercedes Blanch, Lluis Artigas, Antonio Kacmarek, Robert M. PLoS One Research Article BACKGROUND: There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examined whether serial serum levels of LBP could be used as a marker of outcome. METHODOLOGY/PRINCIPAL FINDINGS: LBP serum levels at study entry, at 48 hours and at day-7 were measured in 180 patients with severe sepsis. Data regarding the nature of infections, disease severity, development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), and intensive care unit (ICU) outcome were recorded. LBP serum levels were similar in survivors and non-survivors at study entry (117.4±75.7 µg/mL vs. 129.8±71.3 µg/mL, P = 0.249) but there were significant differences at 48 hours (77.2±57.0 vs. 121.2±73.4 µg/mL, P<0.0001) and at day-7 (64.7±45.8 vs. 89.7±61.1 µg/ml, p = 0.017). At 48 hours, LBP levels were significantly higher in ARDS patients than in ALI patients (112.5±71.8 µg/ml vs. 76.6±55.9 µg/ml, P = 0.0001). An increase of LBP levels at 48 hours was associated with higher mortality (odds ratio 3.97; 95%CI: 1.84–8.56; P<0.001). CONCLUSIONS/SIGNIFICANCE: Serial LBP serum measurements may offer a clinically useful biomarker for identification of patients with severe sepsis having the worst outcomes and the highest probability of developing sepsis-induced ARDS. Public Library of Science 2009-08-31 /pmc/articles/PMC2730016/ /pubmed/19718443 http://dx.doi.org/10.1371/journal.pone.0006818 Text en Villar et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Villar, Jesús
Pérez-Méndez, Lina
Espinosa, Elena
Flores, Carlos
Blanco, Jesús
Muriel, Arturo
Basaldúa, Santiago
Muros, Mercedes
Blanch, Lluis
Artigas, Antonio
Kacmarek, Robert M.
Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title_full Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title_fullStr Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title_full_unstemmed Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title_short Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis
title_sort serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730016/
https://www.ncbi.nlm.nih.gov/pubmed/19718443
http://dx.doi.org/10.1371/journal.pone.0006818
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