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Does blood transfusion harm cardiac surgery patients?

Over recent years there has been a substantial body of evidence demonstrating strong associations between transfusion and adverse outcomes, including myocardial, neurological and renal injury, in a range of clinical settings where transfusion is administered for reasons other than life-threatening b...

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Detalles Bibliográficos
Autor principal: Murphy, Gavin J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730203/
https://www.ncbi.nlm.nih.gov/pubmed/19646222
http://dx.doi.org/10.1186/1741-7015-7-38
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author Murphy, Gavin J
author_facet Murphy, Gavin J
author_sort Murphy, Gavin J
collection PubMed
description Over recent years there has been a substantial body of evidence demonstrating strong associations between transfusion and adverse outcomes, including myocardial, neurological and renal injury, in a range of clinical settings where transfusion is administered for reasons other than life-threatening bleeding. The strength of these associations across a range of clinical settings suggests that confounding and bias, the chief limitations of all observational studies, are unlikely to account for all of these observations. Given the wide range in transfusion rates in cardiac centres, with up to 100% of patients in some centres exposed to allogenic blood components, this evidence, albeit circumstantial, presents a strong argument for prospective randomised trials to attempt to determine, firstly, if transfusion causes adverse outcomes, and secondly, in which patient groups does the benefit of transfusion outweigh these risks? These issues are discussed in the context of an article published this month in BMC Medicine.
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spelling pubmed-27302032009-08-22 Does blood transfusion harm cardiac surgery patients? Murphy, Gavin J BMC Med Commentary Over recent years there has been a substantial body of evidence demonstrating strong associations between transfusion and adverse outcomes, including myocardial, neurological and renal injury, in a range of clinical settings where transfusion is administered for reasons other than life-threatening bleeding. The strength of these associations across a range of clinical settings suggests that confounding and bias, the chief limitations of all observational studies, are unlikely to account for all of these observations. Given the wide range in transfusion rates in cardiac centres, with up to 100% of patients in some centres exposed to allogenic blood components, this evidence, albeit circumstantial, presents a strong argument for prospective randomised trials to attempt to determine, firstly, if transfusion causes adverse outcomes, and secondly, in which patient groups does the benefit of transfusion outweigh these risks? These issues are discussed in the context of an article published this month in BMC Medicine. BioMed Central 2009-07-31 /pmc/articles/PMC2730203/ /pubmed/19646222 http://dx.doi.org/10.1186/1741-7015-7-38 Text en Copyright © 2009 Murphy; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Murphy, Gavin J
Does blood transfusion harm cardiac surgery patients?
title Does blood transfusion harm cardiac surgery patients?
title_full Does blood transfusion harm cardiac surgery patients?
title_fullStr Does blood transfusion harm cardiac surgery patients?
title_full_unstemmed Does blood transfusion harm cardiac surgery patients?
title_short Does blood transfusion harm cardiac surgery patients?
title_sort does blood transfusion harm cardiac surgery patients?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730203/
https://www.ncbi.nlm.nih.gov/pubmed/19646222
http://dx.doi.org/10.1186/1741-7015-7-38
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