Sampling Bias in the Molecular Epidemiology of Tuberculosis

Among the goals of the molecular epidemiology of infectious disease are to quantify the extent of ongoing transmission of infectious agents and to identify host- and strain-specific risk factors for disease spread. I demonstrate the potential bias in estimates of recent transmission and the impact o...

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Detalles Bibliográficos
Autor principal: Murray, Megan
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2002
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730247/
https://www.ncbi.nlm.nih.gov/pubmed/11971768
http://dx.doi.org/10.3201/eid0804.000444
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author Murray, Megan
author_facet Murray, Megan
author_sort Murray, Megan
collection PubMed
description Among the goals of the molecular epidemiology of infectious disease are to quantify the extent of ongoing transmission of infectious agents and to identify host- and strain-specific risk factors for disease spread. I demonstrate the potential bias in estimates of recent transmission and the impact of risk factors for clustering by using computer simulations to reconstruct populations of tuberculosis patients and sample from them. The bias consistently results in underestimating recent transmission and the impact of risk factors for recent transmission.
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spelling pubmed-27302472009-09-16 Sampling Bias in the Molecular Epidemiology of Tuberculosis Murray, Megan Emerg Infect Dis Research Among the goals of the molecular epidemiology of infectious disease are to quantify the extent of ongoing transmission of infectious agents and to identify host- and strain-specific risk factors for disease spread. I demonstrate the potential bias in estimates of recent transmission and the impact of risk factors for clustering by using computer simulations to reconstruct populations of tuberculosis patients and sample from them. The bias consistently results in underestimating recent transmission and the impact of risk factors for recent transmission. Centers for Disease Control and Prevention 2002-04 /pmc/articles/PMC2730247/ /pubmed/11971768 http://dx.doi.org/10.3201/eid0804.000444 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Murray, Megan
Sampling Bias in the Molecular Epidemiology of Tuberculosis
title Sampling Bias in the Molecular Epidemiology of Tuberculosis
title_full Sampling Bias in the Molecular Epidemiology of Tuberculosis
title_fullStr Sampling Bias in the Molecular Epidemiology of Tuberculosis
title_full_unstemmed Sampling Bias in the Molecular Epidemiology of Tuberculosis
title_short Sampling Bias in the Molecular Epidemiology of Tuberculosis
title_sort sampling bias in the molecular epidemiology of tuberculosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730247/
https://www.ncbi.nlm.nih.gov/pubmed/11971768
http://dx.doi.org/10.3201/eid0804.000444
work_keys_str_mv AT murraymegan samplingbiasinthemolecularepidemiologyoftuberculosis

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