Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China

We report the genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus (CCHFV). Two CCHFV strains isolated in Xinjiang Province, a region endemic for CCHF in northwestern China, were studied. These strains, designated BA66019 and BA8402, were isolated in 1965 and 1984 f...

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Autores principales: Papa, Anna, Ma, Benjiang, Kouidou, Sophie, Tang, Qing, Hang, Changshou, Antoniadis, Antonis
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2002
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730268/
https://www.ncbi.nlm.nih.gov/pubmed/11799748
http://dx.doi.org/10.3201/eid0801.010087
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author Papa, Anna
Ma, Benjiang
Kouidou, Sophie
Tang, Qing
Hang, Changshou
Antoniadis, Antonis
author_facet Papa, Anna
Ma, Benjiang
Kouidou, Sophie
Tang, Qing
Hang, Changshou
Antoniadis, Antonis
author_sort Papa, Anna
collection PubMed
description We report the genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus (CCHFV). Two CCHFV strains isolated in Xinjiang Province, a region endemic for CCHF in northwestern China, were studied. These strains, designated BA66019 and BA8402, were isolated in 1965 and 1984 from a CCHF patient and Hyalomma ticks, respectively. Viral RNA was extracted from suckling mouse brains infected with these two strains, amplified, and sequenced. The full-length M RNA, consisting of 5.3 kb, was determined for both strains. The coding nucleotide sequences of the two strains differed from each other by 17.5% and from the reference CCHFV strain IbAr10200 by a mean of 22%, suggesting that the genus Nairovirus comprises a group of genetically highly diverse strains.
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spelling pubmed-27302682009-09-16 Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China Papa, Anna Ma, Benjiang Kouidou, Sophie Tang, Qing Hang, Changshou Antoniadis, Antonis Emerg Infect Dis Research We report the genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus (CCHFV). Two CCHFV strains isolated in Xinjiang Province, a region endemic for CCHF in northwestern China, were studied. These strains, designated BA66019 and BA8402, were isolated in 1965 and 1984 from a CCHF patient and Hyalomma ticks, respectively. Viral RNA was extracted from suckling mouse brains infected with these two strains, amplified, and sequenced. The full-length M RNA, consisting of 5.3 kb, was determined for both strains. The coding nucleotide sequences of the two strains differed from each other by 17.5% and from the reference CCHFV strain IbAr10200 by a mean of 22%, suggesting that the genus Nairovirus comprises a group of genetically highly diverse strains. Centers for Disease Control and Prevention 2002-01 /pmc/articles/PMC2730268/ /pubmed/11799748 http://dx.doi.org/10.3201/eid0801.010087 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Papa, Anna
Ma, Benjiang
Kouidou, Sophie
Tang, Qing
Hang, Changshou
Antoniadis, Antonis
Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title_full Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title_fullStr Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title_full_unstemmed Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title_short Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China
title_sort genetic characterization of the m rna segment of crimean congo hemorrhagic fever virus strains, china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730268/
https://www.ncbi.nlm.nih.gov/pubmed/11799748
http://dx.doi.org/10.3201/eid0801.010087
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