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Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

Objective To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Design Within person, knee matched, case-control study. Setting and participants Participants in the Multicenter Osteoarthritis (MOST) and Framingha...

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Autores principales: Neogi, Tuhina, Felson, David, Niu, Jingbo, Nevitt, Michael, Lewis, Cora E, Aliabadi, Piran, Sack, Burt, Torner, James, Bradley, Lawrence, Zhang, Yuqing
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730438/
https://www.ncbi.nlm.nih.gov/pubmed/19700505
http://dx.doi.org/10.1136/bmj.b2844
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author Neogi, Tuhina
Felson, David
Niu, Jingbo
Nevitt, Michael
Lewis, Cora E
Aliabadi, Piran
Sack, Burt
Torner, James
Bradley, Lawrence
Zhang, Yuqing
author_facet Neogi, Tuhina
Felson, David
Niu, Jingbo
Nevitt, Michael
Lewis, Cora E
Aliabadi, Piran
Sack, Burt
Torner, James
Bradley, Lawrence
Zhang, Yuqing
author_sort Neogi, Tuhina
collection PubMed
description Objective To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Design Within person, knee matched, case-control study. Setting and participants Participants in the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis studies who had knee radiographs and assessments of knee pain. Main outcome measures Association of each pain measure (frequency, consistency, and severity) with radiographic osteoarthritis, as assessed by Kellgren and Lawrence grade (0-4) and osteophyte and joint space narrowing grades (0-3) among matched sets of two knees within individual participants whose knees were discordant for pain status. Results 696 people from MOST and 336 people from Framingham were included. Kellgren and Lawrence grades were strongly associated with frequent knee pain—for example, for Kellgren and Lawrence grade 4 v grade 0 the odds ratio for pain was 151 (95% confidence interval 43 to 526) in MOST and 73 (16 to 331) in Framingham (both P<0.001 for trend). Similar results were also seen for the relation of Kellgren and Lawrence scores to consistency and severity of knee pain. Joint space narrowing was more strongly associated with each pain measure than were osteophytes. Conclusions Using a method that minimises between person confounding, this study found that radiographic osteoarthritis and individual radiographic features of osteoarthritis were strongly associated with knee pain.
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spelling pubmed-27304382009-09-02 Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies Neogi, Tuhina Felson, David Niu, Jingbo Nevitt, Michael Lewis, Cora E Aliabadi, Piran Sack, Burt Torner, James Bradley, Lawrence Zhang, Yuqing BMJ Research Objective To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Design Within person, knee matched, case-control study. Setting and participants Participants in the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis studies who had knee radiographs and assessments of knee pain. Main outcome measures Association of each pain measure (frequency, consistency, and severity) with radiographic osteoarthritis, as assessed by Kellgren and Lawrence grade (0-4) and osteophyte and joint space narrowing grades (0-3) among matched sets of two knees within individual participants whose knees were discordant for pain status. Results 696 people from MOST and 336 people from Framingham were included. Kellgren and Lawrence grades were strongly associated with frequent knee pain—for example, for Kellgren and Lawrence grade 4 v grade 0 the odds ratio for pain was 151 (95% confidence interval 43 to 526) in MOST and 73 (16 to 331) in Framingham (both P<0.001 for trend). Similar results were also seen for the relation of Kellgren and Lawrence scores to consistency and severity of knee pain. Joint space narrowing was more strongly associated with each pain measure than were osteophytes. Conclusions Using a method that minimises between person confounding, this study found that radiographic osteoarthritis and individual radiographic features of osteoarthritis were strongly associated with knee pain. BMJ Publishing Group Ltd. 2009-08-21 /pmc/articles/PMC2730438/ /pubmed/19700505 http://dx.doi.org/10.1136/bmj.b2844 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
Neogi, Tuhina
Felson, David
Niu, Jingbo
Nevitt, Michael
Lewis, Cora E
Aliabadi, Piran
Sack, Burt
Torner, James
Bradley, Lawrence
Zhang, Yuqing
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title_full Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title_fullStr Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title_full_unstemmed Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title_short Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
title_sort association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730438/
https://www.ncbi.nlm.nih.gov/pubmed/19700505
http://dx.doi.org/10.1136/bmj.b2844
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