Caspase-12 and the Inflammatory Response to Yersinia pestis

BACKGROUND: Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility to sepsis in individuals with functional caspase-12, an early-stop mutation leading to the loss of caspase-12 has replaced the ancient genotype in Eurasia a...

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Detalles Bibliográficos
Autores principales: Ferwerda, Bart, McCall, Matthew B. B., de Vries, Maaike C., Hopman, Joost, Maiga, Boubacar, Dolo, Amagana, Doumbo, Ogobara, Daou, Modibo, de Jong, Dirk, Joosten, Leo A. B., Tissingh, Rudi A., Reubsaet, Frans A. G., Sauerwein, Robert, van der Meer, Jos W. M., van der Ven, André J. A. M., Netea, Mihai G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730527/
https://www.ncbi.nlm.nih.gov/pubmed/19721713
http://dx.doi.org/10.1371/journal.pone.0006870

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