Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacteria...

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Detalles Bibliográficos
Autores principales: Feng, Haihua, Xiang, Hua, Zhang, Jiyu, Liu, Guowen, Guo, Na, Wang, Xuelin, Wu, Xiuping, Deng, Xuming, Yu, Lu
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730559/
https://www.ncbi.nlm.nih.gov/pubmed/19707532
http://dx.doi.org/10.1155/2009/617509
Descripción
Sumario:Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.

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