Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacteria...

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Autores principales: Feng, Haihua, Xiang, Hua, Zhang, Jiyu, Liu, Guowen, Guo, Na, Wang, Xuelin, Wu, Xiuping, Deng, Xuming, Yu, Lu
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730559/
https://www.ncbi.nlm.nih.gov/pubmed/19707532
http://dx.doi.org/10.1155/2009/617509
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author Feng, Haihua
Xiang, Hua
Zhang, Jiyu
Liu, Guowen
Guo, Na
Wang, Xuelin
Wu, Xiuping
Deng, Xuming
Yu, Lu
author_facet Feng, Haihua
Xiang, Hua
Zhang, Jiyu
Liu, Guowen
Guo, Na
Wang, Xuelin
Wu, Xiuping
Deng, Xuming
Yu, Lu
author_sort Feng, Haihua
collection PubMed
description Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.
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spelling pubmed-27305592009-08-25 Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone Feng, Haihua Xiang, Hua Zhang, Jiyu Liu, Guowen Guo, Na Wang, Xuelin Wu, Xiuping Deng, Xuming Yu, Lu J Biomed Biotechnol Research Article Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT. Hindawi Publishing Corporation 2009 2009-08-23 /pmc/articles/PMC2730559/ /pubmed/19707532 http://dx.doi.org/10.1155/2009/617509 Text en Copyright © 2009 Haihua Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Haihua
Xiang, Hua
Zhang, Jiyu
Liu, Guowen
Guo, Na
Wang, Xuelin
Wu, Xiuping
Deng, Xuming
Yu, Lu
Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title_full Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title_fullStr Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title_full_unstemmed Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title_short Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
title_sort genome-wide transcriptional profiling of the response of staphylococcus aureus to cryptotanshinone
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730559/
https://www.ncbi.nlm.nih.gov/pubmed/19707532
http://dx.doi.org/10.1155/2009/617509
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