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Simultaneous detection of many T-cell specificities using combinatorial tetramer staining
The direct detection of antigen-specific T cells using tetramers of soluble peptide-major histocompatibilty complex (pMHC) molecules is widely used in both basic and clinical immunology. However, the number of specificities that can be assessed simultaneously has been a major limitation. Here we des...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731062/ https://www.ncbi.nlm.nih.gov/pubmed/19543286 http://dx.doi.org/10.1038/nmeth.1344 |