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Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-(13)C(6)]-d-glucose tracer in mice

Previous genetic and proteomic studies identified altered activity of various enzymes such as those of fatty acid metabolism and glycogen synthesis after a single toxic dose of valproic acid (VPA) in rats. In this study, we demonstrate the effect of VPA on metabolite synthesis flux rates and the pos...

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Detalles Bibliográficos
Autores principales:	Beger, Richard D., Hansen, Deborah K., Schnackenberg, Laura K., Cross, Brandie M., Fatollahi, Javad J., Lagunero, F. Tracy, Sarnyai, Zoltan, Boros, Laszlo G.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731156/ https://www.ncbi.nlm.nih.gov/pubmed/19718458 http://dx.doi.org/10.1007/s11306-009-0159-1

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