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Negative Regulators of Insulin Signaling Revealed in a Genome-Wide Functional Screen

BACKGROUND: Type 2 diabetes develops due to a combination of insulin resistance and β-cell failure and current therapeutics aim at both of these underlying causes. Several negative regulators of insulin signaling are known and are the subject of drug discovery efforts. We sought to identify novel co...

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Detalles Bibliográficos
Autores principales:	Huang, Shih-Min A., Hancock, Michael K., Pitman, Jeffrey L., Orth, Anthony P., Gekakis, Nicholas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731165/ https://www.ncbi.nlm.nih.gov/pubmed/19727444 http://dx.doi.org/10.1371/journal.pone.0006871

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