A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase (DHFR) as a Modulator of β-Catenin/GSK3 Signaling

The multi-protein β-catenin destruction complex tightly regulates β-catenin protein levels by shuttling β-catenin to the proteasome. Glycogen synthase kinase 3β (GSK3β), a key serine/threonine kinase in the destruction complex, is responsible for several phosphorylation events that mark β-catenin fo...

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Detalles Bibliográficos
Autores principales: Klinghoffer, Richard A., Frazier, Jason, Annis, James, Berndt, Jason D., Roberts, Brian S., Arthur, William T., Lacson, Raul, Zhang, Xiaohua Douglas, Ferrer, Marc, Moon, Randall T., Cleary, Michele A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731218/
https://www.ncbi.nlm.nih.gov/pubmed/19727391
http://dx.doi.org/10.1371/journal.pone.0006892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731218/
https://www.ncbi.nlm.nih.gov/pubmed/19727391
http://dx.doi.org/10.1371/journal.pone.0006892

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