Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target

BACKGROUND: Plasmodium falciparum parasitization of erythrocytes causes a substantial increase in the levels of intracellular fatty acids, notably oleic acid. How parasites acquire this monounsaturated fatty acid has remained enigmatic. Here, we report on the biochemical and enzymatic characterizati...

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Detalles Bibliográficos
Autores principales: Gratraud, Paul, Huws, Enlli, Falkard, Brie, Adjalley, Sophie, Fidock, David A., Berry, Laurence, Jacobs, William R., Baird, Mark S., Vial, Henri, Kremer, Laurent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731242/
https://www.ncbi.nlm.nih.gov/pubmed/19707292
http://dx.doi.org/10.1371/journal.pone.0006889

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