Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

OBJECTIVE: Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in β-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor–activated PI3K isoforms is largely unexplored. We therefore investigated th...

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Detalles Bibliográficos
Autores principales: Pigeau, Gary M., Kolic, Jelena, Ball, Brandon J., Hoppa, Michael B., Wang, Ying W., Rückle, Thomas, Woo, Minna, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731529/
https://www.ncbi.nlm.nih.gov/pubmed/19549714
http://dx.doi.org/10.2337/db08-1371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731529/
https://www.ncbi.nlm.nih.gov/pubmed/19549714
http://dx.doi.org/10.2337/db08-1371

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