Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants

OBJECTIVE: Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects of d...

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Detalles Bibliográficos
Autores principales: Nicolson, Tamara J., Bellomo, Elisa A., Wijesekara, Nadeeja, Loder, Merewyn K., Baldwin, Jocelyn M., Gyulkhandanyan, Armen V., Koshkin, Vasilij, Tarasov, Andrei I., Carzaniga, Raffaella, Kronenberger, Katrin, Taneja, Tarvinder K., da Silva Xavier, Gabriela, Libert, Sarah, Froguel, Philippe, Scharfmann, Raphael, Stetsyuk, Volodymir, Ravassard, Philippe, Parker, Helen, Gribble, Fiona M., Reimann, Frank, Sladek, Robert, Hughes, Stephen J., Johnson, Paul R.V., Masseboeuf, Myriam, Burcelin, Remy, Baldwin, Stephen A., Liu, Ming, Lara-Lemus, Roberto, Arvan, Peter, Schuit, Frans C., Wheeler, Michael B., Chimienti, Fabrice, Rutter, Guy A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731533/
https://www.ncbi.nlm.nih.gov/pubmed/19542200
http://dx.doi.org/10.2337/db09-0551

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