The HBZ gene, a key player in HTLV-1 pathogenesis

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research ef...

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Detalles Bibliográficos
Autores principales: Matsuoka, Masao, Green, Patrick L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731725/
https://www.ncbi.nlm.nih.gov/pubmed/19650892
http://dx.doi.org/10.1186/1742-4690-6-71
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author Matsuoka, Masao
Green, Patrick L
author_facet Matsuoka, Masao
Green, Patrick L
author_sort Matsuoka, Masao
collection PubMed
description Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.
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spelling pubmed-27317252009-08-26 The HBZ gene, a key player in HTLV-1 pathogenesis Matsuoka, Masao Green, Patrick L Retrovirology Review Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis. BioMed Central 2009-08-03 /pmc/articles/PMC2731725/ /pubmed/19650892 http://dx.doi.org/10.1186/1742-4690-6-71 Text en Copyright © 2009 Matsuoka and Green; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Matsuoka, Masao
Green, Patrick L
The HBZ gene, a key player in HTLV-1 pathogenesis
title The HBZ gene, a key player in HTLV-1 pathogenesis
title_full The HBZ gene, a key player in HTLV-1 pathogenesis
title_fullStr The HBZ gene, a key player in HTLV-1 pathogenesis
title_full_unstemmed The HBZ gene, a key player in HTLV-1 pathogenesis
title_short The HBZ gene, a key player in HTLV-1 pathogenesis
title_sort hbz gene, a key player in htlv-1 pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731725/
https://www.ncbi.nlm.nih.gov/pubmed/19650892
http://dx.doi.org/10.1186/1742-4690-6-71
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