Abyssinones and related flavonoids as potential steroidogenesis modulators

Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4' ­OH blocked prenylated flavonone 2b (2­(2', 2'­dimethy...

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Autores principales: Hatti, Kaushik S, Diwakar, Latha, Rao, G Venkateswara, Kush, Anil, Reddy, G Chandrasekara
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2009
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732035/
https://www.ncbi.nlm.nih.gov/pubmed/19759815
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author Hatti, Kaushik S
Diwakar, Latha
Rao, G Venkateswara
Kush, Anil
Reddy, G Chandrasekara
author_facet Hatti, Kaushik S
Diwakar, Latha
Rao, G Venkateswara
Kush, Anil
Reddy, G Chandrasekara
author_sort Hatti, Kaushik S
collection PubMed
description Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4' ­OH blocked prenylated flavonone 2b (2­(2', 2'­dimethyl chroman­6'­yl)­7­hydroxy chroman­4­one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytotoxic data (MCF­7, breast cancer cell line) and docking results indicating flavonone as a better steroidogenesis modulator in hormone dependent cancer.
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spelling pubmed-27320352009-09-16 Abyssinones and related flavonoids as potential steroidogenesis modulators Hatti, Kaushik S Diwakar, Latha Rao, G Venkateswara Kush, Anil Reddy, G Chandrasekara Bioinformation Hypothesis Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4' ­OH blocked prenylated flavonone 2b (2­(2', 2'­dimethyl chroman­6'­yl)­7­hydroxy chroman­4­one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytotoxic data (MCF­7, breast cancer cell line) and docking results indicating flavonone as a better steroidogenesis modulator in hormone dependent cancer. Biomedical Informatics Publishing Group 2009-06-28 /pmc/articles/PMC2732035/ /pubmed/19759815 Text en © 2009 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Hatti, Kaushik S
Diwakar, Latha
Rao, G Venkateswara
Kush, Anil
Reddy, G Chandrasekara
Abyssinones and related flavonoids as potential steroidogenesis modulators
title Abyssinones and related flavonoids as potential steroidogenesis modulators
title_full Abyssinones and related flavonoids as potential steroidogenesis modulators
title_fullStr Abyssinones and related flavonoids as potential steroidogenesis modulators
title_full_unstemmed Abyssinones and related flavonoids as potential steroidogenesis modulators
title_short Abyssinones and related flavonoids as potential steroidogenesis modulators
title_sort abyssinones and related flavonoids as potential steroidogenesis modulators
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732035/
https://www.ncbi.nlm.nih.gov/pubmed/19759815
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