Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

OBJECTIVE: Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. Treatment with recombinant IL-1Ra improves glycemia and β-cell func...

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Detalles Bibliográficos
Autores principales: Larsen, Claus M., Faulenbach, Mirjam, Vaag, Allan, Ehses, Jan A., Donath, Marc Y., Mandrup-Poulsen, Thomas
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732140/
https://www.ncbi.nlm.nih.gov/pubmed/19542207
http://dx.doi.org/10.2337/dc09-0533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732140/
https://www.ncbi.nlm.nih.gov/pubmed/19542207
http://dx.doi.org/10.2337/dc09-0533

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