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Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

OBJECTIVE: Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. Treatment with recombinant IL-1Ra improves glycemia and β-cell func...

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Detalles Bibliográficos
Autores principales:	Larsen, Claus M., Faulenbach, Mirjam, Vaag, Allan, Ehses, Jan A., Donath, Marc Y., Mandrup-Poulsen, Thomas
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732140/ https://www.ncbi.nlm.nih.gov/pubmed/19542207 http://dx.doi.org/10.2337/dc09-0533

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