Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiat...

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Detalles Bibliográficos
Autores principales: Yu, Wen Leong, Pfaller, Michael A., Winokur, Patricia L., Jones, Ronald N.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2002
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732501/
https://www.ncbi.nlm.nih.gov/pubmed/11996691
http://dx.doi.org/10.3201/eid0805.010346
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author Yu, Wen Leong
Pfaller, Michael A.
Winokur, Patricia L.
Jones, Ronald N.
author_facet Yu, Wen Leong
Pfaller, Michael A.
Winokur, Patricia L.
Jones, Ronald N.
author_sort Yu, Wen Leong
collection PubMed
description To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.
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spelling pubmed-27325012009-09-16 Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan Yu, Wen Leong Pfaller, Michael A. Winokur, Patricia L. Jones, Ronald N. Emerg Infect Dis Dispatch To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented. Centers for Disease Control and Prevention 2002-05 /pmc/articles/PMC2732501/ /pubmed/11996691 http://dx.doi.org/10.3201/eid0805.010346 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Yu, Wen Leong
Pfaller, Michael A.
Winokur, Patricia L.
Jones, Ronald N.
Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title_full Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title_fullStr Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title_full_unstemmed Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title_short Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
title_sort cefepime mic as a predictor of the extended-spectrum β-lactamase type in klebsiella pneumoniae, taiwan
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732501/
https://www.ncbi.nlm.nih.gov/pubmed/11996691
http://dx.doi.org/10.3201/eid0805.010346
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AT winokurpatricial cefepimemicasapredictoroftheextendedspectrumblactamasetypeinklebsiellapneumoniaetaiwan
AT jonesronaldn cefepimemicasapredictoroftheextendedspectrumblactamasetypeinklebsiellapneumoniaetaiwan

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