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Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness
Human metapneumovirus (HMPV) is a recently identified Paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (ARTI). We sought evidence of HMPV infection in patients who had visited general practitioners, had influenzalike illnesses (ILI), and had negative te...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732534/ https://www.ncbi.nlm.nih.gov/pubmed/12194763 http://dx.doi.org/10.3201/eid0809.020084 |
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author | Stockton, Joanne Stephenson, Iain Fleming, Douglas Zambon, Maria |
author_facet | Stockton, Joanne Stephenson, Iain Fleming, Douglas Zambon, Maria |
author_sort | Stockton, Joanne |
collection | PubMed |
description | Human metapneumovirus (HMPV) is a recently identified Paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (ARTI). We sought evidence of HMPV infection in patients who had visited general practitioners, had influenzalike illnesses (ILI), and had negative tests for influenza and Human respiratory syncytial virus (HRSV). As part of national virologic surveillance, sentinel general practices in England and Wales collected samples from patients of all ages with ILI during winter 2000–01. Reverse transcriptase-polymerase chain reaction (PCR) for HMPV, influenza A (H1 and H3), influenza B, and HRSV was used to screen combined nose and throat swabs. PCR products from the HMPV-positive samples were sequenced to confirm identity and construct phylogenetic trees. Of 711 swabs submitted, 408 (57.3%) were negative for influenza and HRSV; HMPV was identified in 9 (2.2%) patients. HMPV appears to be associated with community-acquired ARTI. The extent of illness and possible complications related to this new human virus need to be clarified |
format | Text |
id | pubmed-2732534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-27325342009-09-16 Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness Stockton, Joanne Stephenson, Iain Fleming, Douglas Zambon, Maria Emerg Infect Dis Research Human metapneumovirus (HMPV) is a recently identified Paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (ARTI). We sought evidence of HMPV infection in patients who had visited general practitioners, had influenzalike illnesses (ILI), and had negative tests for influenza and Human respiratory syncytial virus (HRSV). As part of national virologic surveillance, sentinel general practices in England and Wales collected samples from patients of all ages with ILI during winter 2000–01. Reverse transcriptase-polymerase chain reaction (PCR) for HMPV, influenza A (H1 and H3), influenza B, and HRSV was used to screen combined nose and throat swabs. PCR products from the HMPV-positive samples were sequenced to confirm identity and construct phylogenetic trees. Of 711 swabs submitted, 408 (57.3%) were negative for influenza and HRSV; HMPV was identified in 9 (2.2%) patients. HMPV appears to be associated with community-acquired ARTI. The extent of illness and possible complications related to this new human virus need to be clarified Centers for Disease Control and Prevention 2002-09 /pmc/articles/PMC2732534/ /pubmed/12194763 http://dx.doi.org/10.3201/eid0809.020084 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Stockton, Joanne Stephenson, Iain Fleming, Douglas Zambon, Maria Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title | Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title_full | Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title_fullStr | Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title_full_unstemmed | Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title_short | Human Metapneumovirus as a Cause of Community-Acquired Respiratory Illness |
title_sort | human metapneumovirus as a cause of community-acquired respiratory illness |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732534/ https://www.ncbi.nlm.nih.gov/pubmed/12194763 http://dx.doi.org/10.3201/eid0809.020084 |
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