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Biofilms: Microbial Life on Surfaces
Microorganisms attach to surfaces and develop biofilms. Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down- regulation of specific genes. Attachment is a compl...
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732559/ https://www.ncbi.nlm.nih.gov/pubmed/12194761 http://dx.doi.org/10.3201/eid0809.020063 |
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author | Donlan, Rodney M. |
author_facet | Donlan, Rodney M. |
author_sort | Donlan, Rodney M. |
collection | PubMed |
description | Microorganisms attach to surfaces and develop biofilms. Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down- regulation of specific genes. Attachment is a complex process regulated by diverse characteristics of the growth medium, substratum, and cell surface. An established biofilm structure comprises microbial cells and EPS, has a defined architecture, and provides an optimal environment for the exchange of genetic material between cells. Cells may also communicate via quorum sensing, which may in turn affect biofilm processes such as detachment. Biofilms have great importance for public health because of their role in certain infectious diseases and importance in a variety of device-related infections. A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management. |
format | Text |
id | pubmed-2732559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-27325592009-09-16 Biofilms: Microbial Life on Surfaces Donlan, Rodney M. Emerg Infect Dis Perspective Microorganisms attach to surfaces and develop biofilms. Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down- regulation of specific genes. Attachment is a complex process regulated by diverse characteristics of the growth medium, substratum, and cell surface. An established biofilm structure comprises microbial cells and EPS, has a defined architecture, and provides an optimal environment for the exchange of genetic material between cells. Cells may also communicate via quorum sensing, which may in turn affect biofilm processes such as detachment. Biofilms have great importance for public health because of their role in certain infectious diseases and importance in a variety of device-related infections. A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management. Centers for Disease Control and Prevention 2002-09 /pmc/articles/PMC2732559/ /pubmed/12194761 http://dx.doi.org/10.3201/eid0809.020063 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Perspective Donlan, Rodney M. Biofilms: Microbial Life on Surfaces |
title | Biofilms: Microbial Life on Surfaces |
title_full | Biofilms: Microbial Life on Surfaces |
title_fullStr | Biofilms: Microbial Life on Surfaces |
title_full_unstemmed | Biofilms: Microbial Life on Surfaces |
title_short | Biofilms: Microbial Life on Surfaces |
title_sort | biofilms: microbial life on surfaces |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732559/ https://www.ncbi.nlm.nih.gov/pubmed/12194761 http://dx.doi.org/10.3201/eid0809.020063 |
work_keys_str_mv | AT donlanrodneym biofilmsmicrobiallifeonsurfaces |