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Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters

BACKGROUND: Modellers using the MWC allosteric framework have often found it difficult to validate their models. Indeed many experiments are not conducted with the notion of alternative conformations in mind and therefore do not (or cannot) measure relevant microscopic constant and parameters. Inste...

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Detalles Bibliográficos
Autores principales: Stefan, Melanie I, Edelstein, Stuart J, Le Novère, Nicolas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732593/
https://www.ncbi.nlm.nih.gov/pubmed/19602261
http://dx.doi.org/10.1186/1752-0509-3-68

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