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Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus
BACKGROUND/AIMS: In type 2 diabetic patients, coronary artery disease (CAD) is usually detected at an advanced stage due to a lack of symptoms. The aim of this study was to define which clinical parameters or non-invasive tests predict CAD in asymptomatic type 2 diabetic patients. METHODS: One hundr...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732776/ https://www.ncbi.nlm.nih.gov/pubmed/19721853 http://dx.doi.org/10.3904/kjim.2009.24.3.183 |
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author | Yoo, Won Sang Kim, Hee Jin Kim, Dohee Lee, Myung Yong Chung, Hyun-Kyung |
author_facet | Yoo, Won Sang Kim, Hee Jin Kim, Dohee Lee, Myung Yong Chung, Hyun-Kyung |
author_sort | Yoo, Won Sang |
collection | PubMed |
description | BACKGROUND/AIMS: In type 2 diabetic patients, coronary artery disease (CAD) is usually detected at an advanced stage due to a lack of symptoms. The aim of this study was to define which clinical parameters or non-invasive tests predict CAD in asymptomatic type 2 diabetic patients. METHODS: One hundred fourteen asymptomatic type 2 diabetic patients were divided into two groups based on the number of cardiovascular disease (CVD) risk factors (group A ≥2, group B ≤1). Treadmill exercise ECG tests (TMT) were conducted in all cases, and coronary artery angiography was performed on TMT-positive patients. Clinical parameters, diabetic status, and coronary angiographic findings were analyzed. RESULTS: The prevalence of CAD was 41.0% in group A and 16.7% in group B. The number of risk factors was significantly correlated with the prevalence of CAD, but not with the severity of CAD. Multivariate analysis showed that family history of CAD (odds ratio [OR]=9.41; 95% confidence interval [CI], 1.60-55.49) and diabetes duration ≥10 years (OR=3.28; 95% CI, 1.29-8.84) were independent CAD risk factors in asymptomatic patients. CONCLUSIONS: We recommend a routine screening for CAD in type 2 diabetic patients who have a longer (≥10 years) diabetic duration or a family history of CAD, even if they are asymptomatic for CAD. |
format | Text |
id | pubmed-2732776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-27327762009-09-01 Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus Yoo, Won Sang Kim, Hee Jin Kim, Dohee Lee, Myung Yong Chung, Hyun-Kyung Korean J Intern Med Original Article BACKGROUND/AIMS: In type 2 diabetic patients, coronary artery disease (CAD) is usually detected at an advanced stage due to a lack of symptoms. The aim of this study was to define which clinical parameters or non-invasive tests predict CAD in asymptomatic type 2 diabetic patients. METHODS: One hundred fourteen asymptomatic type 2 diabetic patients were divided into two groups based on the number of cardiovascular disease (CVD) risk factors (group A ≥2, group B ≤1). Treadmill exercise ECG tests (TMT) were conducted in all cases, and coronary artery angiography was performed on TMT-positive patients. Clinical parameters, diabetic status, and coronary angiographic findings were analyzed. RESULTS: The prevalence of CAD was 41.0% in group A and 16.7% in group B. The number of risk factors was significantly correlated with the prevalence of CAD, but not with the severity of CAD. Multivariate analysis showed that family history of CAD (odds ratio [OR]=9.41; 95% confidence interval [CI], 1.60-55.49) and diabetes duration ≥10 years (OR=3.28; 95% CI, 1.29-8.84) were independent CAD risk factors in asymptomatic patients. CONCLUSIONS: We recommend a routine screening for CAD in type 2 diabetic patients who have a longer (≥10 years) diabetic duration or a family history of CAD, even if they are asymptomatic for CAD. The Korean Association of Internal Medicine 2009-09 2009-08-26 /pmc/articles/PMC2732776/ /pubmed/19721853 http://dx.doi.org/10.3904/kjim.2009.24.3.183 Text en Copyright © 2009 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoo, Won Sang Kim, Hee Jin Kim, Dohee Lee, Myung Yong Chung, Hyun-Kyung Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title | Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title_full | Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title_fullStr | Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title_full_unstemmed | Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title_short | Early Detection Of Asymptomatic Coronary Artery Disease In Patients With Type 2 Diabetes Mellitus |
title_sort | early detection of asymptomatic coronary artery disease in patients with type 2 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732776/ https://www.ncbi.nlm.nih.gov/pubmed/19721853 http://dx.doi.org/10.3904/kjim.2009.24.3.183 |
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