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Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional regulator that in turn initiates a downstream p...

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Detalles Bibliográficos
Autores principales:	Bogani, Debora, Siggers, Pam, Brixey, Rachel, Warr, Nick, Beddow, Sarah, Edwards, Jessica, Williams, Debbie, Wilhelm, Dagmar, Koopman, Peter, Flavell, Richard A., Chi, Hongbo, Ostrer, Harry, Wells, Sara, Cheeseman, Michael, Greenfield, Andy
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733150/ https://www.ncbi.nlm.nih.gov/pubmed/19753101 http://dx.doi.org/10.1371/journal.pbio.1000196

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