Cargando…

Clinical implications of a possible role of vitamin D in multiple sclerosis

Hypovitaminosis D is currently one of the most studied environmental risk factors for multiple sclerosis (MS) and is potentially the most promising in terms of new clinical implications. These practical consequences, which could be applied to MS patients without further delay, constitute the main pu...

Descripción completa

Detalles Bibliográficos
Autor principal: Pierrot-Deseilligny, Charles
Formato: Texto
Lenguaje:English
Publicado: D. Steinkopff-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733195/
https://www.ncbi.nlm.nih.gov/pubmed/19399382
http://dx.doi.org/10.1007/s00415-009-5139-x
_version_ 1782171099261304832
author Pierrot-Deseilligny, Charles
author_facet Pierrot-Deseilligny, Charles
author_sort Pierrot-Deseilligny, Charles
collection PubMed
description Hypovitaminosis D is currently one of the most studied environmental risk factors for multiple sclerosis (MS) and is potentially the most promising in terms of new clinical implications. These practical consequences, which could be applied to MS patients without further delay, constitute the main purpose of this review. Vitamin D is involved in a number of important general actions, which were not even suspected until quite recently. In particular, this vitamin could play an immunomodulatory role in the central nervous system. Many and varied arguments support a significant role for vitamin D in MS. In animal studies, vitamin D prevents and improves experimental autoimmune encephalomyelitis. Epidemiologically, latitude, past exposure to sun and the serum level of vitamin D influence the risk of MS, with, furthermore, significant links existing between these different factors. Clinically, most MS patients have low serum levels of vitamin D and are in a state of insufficiency or even deficiency compared to the international norm, which has been established on a metabolic basis. Large therapeutic trials using vitamin D are still lacking but the first results of phase I/II studies are promising. In the meantime, while awaiting the results of future therapeutic trials, it can no longer be ignored that many MS patients have a lack of vitamin D, which could be detected by a serum titration and corrected using an appropriate vitamin D supplementation in order to restore their serum level to within the normal range. From a purely medical point of view, vitamin D supplementation appears in this light to be unavoidable in order to improve the general state of these patients. Furthermore, it cannot currently be ruled out that this supplementation could also be neurologically beneficial.
format Text
id pubmed-2733195
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher D. Steinkopff-Verlag
record_format MEDLINE/PubMed
spelling pubmed-27331952009-08-28 Clinical implications of a possible role of vitamin D in multiple sclerosis Pierrot-Deseilligny, Charles J Neurol Original Communication Hypovitaminosis D is currently one of the most studied environmental risk factors for multiple sclerosis (MS) and is potentially the most promising in terms of new clinical implications. These practical consequences, which could be applied to MS patients without further delay, constitute the main purpose of this review. Vitamin D is involved in a number of important general actions, which were not even suspected until quite recently. In particular, this vitamin could play an immunomodulatory role in the central nervous system. Many and varied arguments support a significant role for vitamin D in MS. In animal studies, vitamin D prevents and improves experimental autoimmune encephalomyelitis. Epidemiologically, latitude, past exposure to sun and the serum level of vitamin D influence the risk of MS, with, furthermore, significant links existing between these different factors. Clinically, most MS patients have low serum levels of vitamin D and are in a state of insufficiency or even deficiency compared to the international norm, which has been established on a metabolic basis. Large therapeutic trials using vitamin D are still lacking but the first results of phase I/II studies are promising. In the meantime, while awaiting the results of future therapeutic trials, it can no longer be ignored that many MS patients have a lack of vitamin D, which could be detected by a serum titration and corrected using an appropriate vitamin D supplementation in order to restore their serum level to within the normal range. From a purely medical point of view, vitamin D supplementation appears in this light to be unavoidable in order to improve the general state of these patients. Furthermore, it cannot currently be ruled out that this supplementation could also be neurologically beneficial. D. Steinkopff-Verlag 2009-04-28 2009-09 /pmc/articles/PMC2733195/ /pubmed/19399382 http://dx.doi.org/10.1007/s00415-009-5139-x Text en © The Author(s) 2009
spellingShingle Original Communication
Pierrot-Deseilligny, Charles
Clinical implications of a possible role of vitamin D in multiple sclerosis
title Clinical implications of a possible role of vitamin D in multiple sclerosis
title_full Clinical implications of a possible role of vitamin D in multiple sclerosis
title_fullStr Clinical implications of a possible role of vitamin D in multiple sclerosis
title_full_unstemmed Clinical implications of a possible role of vitamin D in multiple sclerosis
title_short Clinical implications of a possible role of vitamin D in multiple sclerosis
title_sort clinical implications of a possible role of vitamin d in multiple sclerosis
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733195/
https://www.ncbi.nlm.nih.gov/pubmed/19399382
http://dx.doi.org/10.1007/s00415-009-5139-x
work_keys_str_mv AT pierrotdeseillignycharles clinicalimplicationsofapossibleroleofvitamindinmultiplesclerosis