Cargando…

Trans−cis Switching Mechanisms in Proline Analogues and Their Relevance for the Gating of the 5-HT(3) Receptor

[Image: see text] Trans−cis isomerization of a proline peptide bond is a potential mechanism to open the channel of the 5-HT(3) receptor. Here, we have used the metadynamics method to theoretically explore such a mechanism. We have determined the free energy surfaces in aqueous solution of a series...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melis, Claudio, Bussi, Giovanni, Lummis, Sarah C. R., Molteni, Carla
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2009
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733763/ https://www.ncbi.nlm.nih.gov/pubmed/19663504 http://dx.doi.org/10.1021/jp9046962

Ejemplares similares

PBOND: Web Server for the Prediction of Proline and Non-Proline cis/trans Isomerization
por: Exarchos, Konstantinos P., et al.
Publicado: (2009)

Molecular Dynamics Simulations of GABA Binding to the GABA(C) Receptor: The Role of Arg(104)
por: Melis, Claudio, et al.
Publicado: (2008)

Proline cis-trans isomerization is influenced by local lysine acetylation-deacetylation
por: Howe, Françoise S., et al.
Publicado: (2014)

cis–trans-Amide isomerism of the 3,4-dehydroproline residue, the ‘unpuckered’ proline
por: Kubyshkin, Vladimir, et al.
Publicado: (2016)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors
por: Rienzo, Matthew, et al.
Publicado: (2016)

Role of cis-trans proline isomerization in the function of pathogenic enterobacterial Periplasmic Binding Proteins
por: Cortes-Hernandez, Paulina, et al.
Publicado: (2017)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Structural insight into proline cis/trans isomerization of unfolded proteins catalyzed by the trigger factor chaperone
por: Kawagoe, Soichiro, et al.
Publicado: (2018)

The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85
por: Troilo, Francesca, et al.
Publicado: (2019)

Automated Radiosynthesis of cis- and trans-4-[(18)F]Fluoro-l-proline Using [(18)F]Fluoride
por: Morgan, Timaeus E. F., et al.
Publicado: (2021)

A single channel mutation alters agonist efficacy at 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, A J, et al.
Publicado: (2013)

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT(3)A and 5-HT(3)AB receptors()
por: Lummis, Sarah C.R., et al.
Publicado: (2013)

A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism
por: Crnjar, Alessandro, et al.
Publicado: (2021)

5-HT(3) Receptor MX Helix Contributes to Receptor Function
por: Mocatta, James, et al.
Publicado: (2022)

Enzymatic production of trans‐4‐hydroxy‐l‐proline by proline 4‐hydroxylase
por: Chen, Xiulai, et al.
Publicado: (2020)

Selective (1)H(α) NMR Methods Reveal Functionally Relevant Proline cis/trans Isomers in Intrinsically Disordered Proteins: Characterization of Minor Forms, Effects of Phosphorylation, and Occurrence in Proteome
por: Sebák, Fanni, et al.
Publicado: (2021)

Preparation of Phosphonic Acid Analogues of Proline and Proline Analogues and Their Biological Evaluation as δ(1)-Pyrroline-5-carboxylate Reductase Inhibitors
por: Qian, Renzhe, et al.
Publicado: (2018)

Loop B Is a Major Structural Component of the 5-HT(3) Receptor
por: Thompson, A. J., et al.
Publicado: (2008)

Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT(3) receptor via a common vestibule site
por: Brams, Marijke, et al.
Publicado: (2020)

Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases
por: Klein, Christian, et al.
Publicado: (2011)

Proline substitutions in a Mip-like peptidyl-prolyl cis-trans isomerase severely affect its structure, stability, shape and activity
por: Polley, Soumitra, et al.
Publicado: (2015)

Detection of human and rodent 5-HT(3B )receptor subunits by anti-peptide polyclonal antibodies
por: Reeves, David C, et al.
Publicado: (2006)

Proline and Proline Analogues Improve Development of Mouse Preimplantation Embryos by Protecting Them against Oxidative Stress
por: Hardy, Madeleine L. M., et al.
Publicado: (2023)

Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues
por: Lummis, Sarah C. R., et al.
Publicado: (2022)

High-affinity fluorescent ligands for the 5-HT(3) receptor
por: Simonin, Jonathan, et al.
Publicado: (2012)

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors
Publicado: (1993)

Cis- and trans-regulation in X inactivation
por: van Bemmel, Joke G., et al.
Publicado: (2015)

Relative Stability of cis- and trans-Hydrindanones
por: Tori, Motoo
Publicado: (2015)

Varenicline Interactions at the 5-HT(3) Receptor Ligand Binding Site are Revealed by 5-HTBP
por: Price, Kerry L., et al.
Publicado: (2015)

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor
por: Thompson, Andrew J., et al.
Publicado: (2012)

Structure–Activity Relationships of Quinoxaline-Based 5-HT(3)A and 5-HT(3)AB Receptor-Selective Ligands
por: Thompson, Andrew J, et al.
Publicado: (2013)

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, Andrew J., et al.
Publicado: (2014)

Age-Dependent Switch of the Role of Serotonergic 5-HT(1A) Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo
por: Gagolewicz, Peter J., et al.
Publicado: (2016)

Apoptotic and non-apoptotic cell death induced by cis and trans analogues of a novel ammine(cyclohexylamine)dihydroxodichloroplatinum(IV) complex.
por: O'Neill, C. F., et al.
Publicado: (1996)

Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT(3)AB receptors
por: Thompson, A J, et al.
Publicado: (2011)

cis–trans Isomerization of silybins A and B
por: Novotná, Michaela, et al.
Publicado: (2014)

Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel
por: Nesci, Salvatore
Publicado: (2022)

Detection of discriminative sequence patterns in the neighborhood of proline cis peptide bonds and their functional annotation
por: Exarchos, Konstantinos P, et al.
Publicado: (2009)

Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase
por: Watanabe, Seiya, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jt7avmoucvmtq4is9jsclii6ns