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Slow progressive conduction and contraction defects in loss of Nkx2–5 mice after cardiomyocyte terminal differentiation
Mutations in homeoprotein NKX2–5 are linked to human congenital heart disease resulting in various cardiac anomalies, as well as postnatal progressive conduction defects and occasional left ventricular dysfunction, yet the function of Nkx2–5 in the postnatal period is largely unexplored. In the hear...
Autores principales: | Takeda, Morihiko, Briggs, Laura E., Wakimoto, Hiroko, Marks, Melissa H., Warren, Sonisha A., Lu, Jonathan T., Weinberg, Ellen O., Robertson, Keith D., Chien, Kenneth R., Kasahara, Hideko |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733927/ https://www.ncbi.nlm.nih.gov/pubmed/19546853 http://dx.doi.org/10.1038/labinvest.2009.59 |
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