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Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms

Mesenchymal hamartoma (MH) of the liver is an uncommon benign lesion related to ductal plate malformation. It is usually cystic and mainly composed of myxoid mesenchymal tissue with tortuous or cystic bile ducts. In order to characterize the clinicopathological features of MH, the Korean Gastrointes...

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Autores principales: Chang, Hee Jin, Jin, So Young, Park, Chanil, Park, Young Nyun, Jang, Ja June, Park, Cheol Keun, Suh, Yeon Lim, Yu, Eunsil, Kang, Dae Young, Bae, Han Ik
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733981/
https://www.ncbi.nlm.nih.gov/pubmed/16479067
http://dx.doi.org/10.3346/jkms.2006.21.1.63
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author Chang, Hee Jin
Jin, So Young
Park, Chanil
Park, Young Nyun
Jang, Ja June
Park, Cheol Keun
Suh, Yeon Lim
Yu, Eunsil
Kang, Dae Young
Bae, Han Ik
author_facet Chang, Hee Jin
Jin, So Young
Park, Chanil
Park, Young Nyun
Jang, Ja June
Park, Cheol Keun
Suh, Yeon Lim
Yu, Eunsil
Kang, Dae Young
Bae, Han Ik
author_sort Chang, Hee Jin
collection PubMed
description Mesenchymal hamartoma (MH) of the liver is an uncommon benign lesion related to ductal plate malformation. It is usually cystic and mainly composed of myxoid mesenchymal tissue with tortuous or cystic bile ducts. In order to characterize the clinicopathological features of MH, the Korean Gastrointestinal Pathology Study Group collected a total of 17 MH cases diagnosed in 7 hospitals from 1992 to 2002 and compared the clinicopathologic findings of cystic MH with those of solid variant. Among the 17 cases, 7 (41%) were solid. The solid form showed a higher serum level of α-fetoprotein (AFP), the smaller bile ducts, and more frequent proliferation of vessels. Serum AFP level was related to the amount of hepatocytes. Two of seven solid cases harbored a larger amount of evenly distributed hepatocytes and proliferation of small duct with focal hepatocyte-bile duct transition. These histologic findings are similar to those of mixed hamartoma. Therefore, the mixed hamartoma and the MH of both solid and cystic types could be the variants of one disease spectrum. And hepatocytes within MH might be rather a genuine tumor component than entrapped into the tumor. In conclusion, MH can show various clinicopathological features and recognition of these features will facilitate accurate diagnosis of MH.
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spelling pubmed-27339812009-08-31 Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms Chang, Hee Jin Jin, So Young Park, Chanil Park, Young Nyun Jang, Ja June Park, Cheol Keun Suh, Yeon Lim Yu, Eunsil Kang, Dae Young Bae, Han Ik J Korean Med Sci Original Article Mesenchymal hamartoma (MH) of the liver is an uncommon benign lesion related to ductal plate malformation. It is usually cystic and mainly composed of myxoid mesenchymal tissue with tortuous or cystic bile ducts. In order to characterize the clinicopathological features of MH, the Korean Gastrointestinal Pathology Study Group collected a total of 17 MH cases diagnosed in 7 hospitals from 1992 to 2002 and compared the clinicopathologic findings of cystic MH with those of solid variant. Among the 17 cases, 7 (41%) were solid. The solid form showed a higher serum level of α-fetoprotein (AFP), the smaller bile ducts, and more frequent proliferation of vessels. Serum AFP level was related to the amount of hepatocytes. Two of seven solid cases harbored a larger amount of evenly distributed hepatocytes and proliferation of small duct with focal hepatocyte-bile duct transition. These histologic findings are similar to those of mixed hamartoma. Therefore, the mixed hamartoma and the MH of both solid and cystic types could be the variants of one disease spectrum. And hepatocytes within MH might be rather a genuine tumor component than entrapped into the tumor. In conclusion, MH can show various clinicopathological features and recognition of these features will facilitate accurate diagnosis of MH. The Korean Academy of Medical Sciences 2006-02 2006-02-20 /pmc/articles/PMC2733981/ /pubmed/16479067 http://dx.doi.org/10.3346/jkms.2006.21.1.63 Text en Copyright © 2006 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Hee Jin
Jin, So Young
Park, Chanil
Park, Young Nyun
Jang, Ja June
Park, Cheol Keun
Suh, Yeon Lim
Yu, Eunsil
Kang, Dae Young
Bae, Han Ik
Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title_full Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title_fullStr Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title_full_unstemmed Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title_short Mesenchymal Hamartomas of the Liver: Comparison of Clinicopathologic Features between Cystic and Solid Forms
title_sort mesenchymal hamartomas of the liver: comparison of clinicopathologic features between cystic and solid forms
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733981/
https://www.ncbi.nlm.nih.gov/pubmed/16479067
http://dx.doi.org/10.3346/jkms.2006.21.1.63
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