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Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease

Diseases of the peripheral nervous system are the most prevalent in patients with end-stage renal disease (ESRD). Although increased blood levels of lead in ESRD have been reported, the role of lead remains to be elucidated. The purpose of this study was to determine the connection of blood lead con...

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Autores principales: Kim, Yeng-Soo, Park, Jae-Ho, Hong, Joong-Rock, Gil, Hyo-Wook, Yang, Jong-Oh, Lee, Eun-Young, Hong, Sae-Yong
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734006/
https://www.ncbi.nlm.nih.gov/pubmed/16614516
http://dx.doi.org/10.3346/jkms.2006.21.2.290
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author Kim, Yeng-Soo
Park, Jae-Ho
Hong, Joong-Rock
Gil, Hyo-Wook
Yang, Jong-Oh
Lee, Eun-Young
Hong, Sae-Yong
author_facet Kim, Yeng-Soo
Park, Jae-Ho
Hong, Joong-Rock
Gil, Hyo-Wook
Yang, Jong-Oh
Lee, Eun-Young
Hong, Sae-Yong
author_sort Kim, Yeng-Soo
collection PubMed
description Diseases of the peripheral nervous system are the most prevalent in patients with end-stage renal disease (ESRD). Although increased blood levels of lead in ESRD have been reported, the role of lead remains to be elucidated. The purpose of this study was to determine the connection of blood lead concentration with peripheral nerve conduction velocity. One hundred ninety-eight healthy subjects (control group) and 68 patients with ESRD undergoing hemodialysis (ESRD group) were enrolled. Nerve conduction was measured within two hours after hemodialysis. Orthodromic sensory nerve action potentials and compound muscle action potentials were recorded on the median, ulnar, and radial nerves. Hemoglobin-corrected blood lead was significantly higher in ESRD patients than in controls (9.1±2.8 µg/dL vs. 5.9±2.3 µg/dL, p<0.001). 32.4% of 68 ESRD patients with diabetes mellitus were significantly related to poorer motor and sensory nerve conduction velocity (p<0.001). However, blood lead was not a significant predictor of the nerve conduction velocity (p>0.05). Our result suggested that even though the blood lead levels were high in ESRD, they were not associated with the decline of peripheral nerve function. Diabetes mellitus is a primary independent risk of neuropathy in ESRD patients.
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spelling pubmed-27340062009-08-31 Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease Kim, Yeng-Soo Park, Jae-Ho Hong, Joong-Rock Gil, Hyo-Wook Yang, Jong-Oh Lee, Eun-Young Hong, Sae-Yong J Korean Med Sci Original Article Diseases of the peripheral nervous system are the most prevalent in patients with end-stage renal disease (ESRD). Although increased blood levels of lead in ESRD have been reported, the role of lead remains to be elucidated. The purpose of this study was to determine the connection of blood lead concentration with peripheral nerve conduction velocity. One hundred ninety-eight healthy subjects (control group) and 68 patients with ESRD undergoing hemodialysis (ESRD group) were enrolled. Nerve conduction was measured within two hours after hemodialysis. Orthodromic sensory nerve action potentials and compound muscle action potentials were recorded on the median, ulnar, and radial nerves. Hemoglobin-corrected blood lead was significantly higher in ESRD patients than in controls (9.1±2.8 µg/dL vs. 5.9±2.3 µg/dL, p<0.001). 32.4% of 68 ESRD patients with diabetes mellitus were significantly related to poorer motor and sensory nerve conduction velocity (p<0.001). However, blood lead was not a significant predictor of the nerve conduction velocity (p>0.05). Our result suggested that even though the blood lead levels were high in ESRD, they were not associated with the decline of peripheral nerve function. Diabetes mellitus is a primary independent risk of neuropathy in ESRD patients. The Korean Academy of Medical Sciences 2006-04 2006-04-20 /pmc/articles/PMC2734006/ /pubmed/16614516 http://dx.doi.org/10.3346/jkms.2006.21.2.290 Text en Copyright © 2006 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Yeng-Soo
Park, Jae-Ho
Hong, Joong-Rock
Gil, Hyo-Wook
Yang, Jong-Oh
Lee, Eun-Young
Hong, Sae-Yong
Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title_full Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title_fullStr Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title_full_unstemmed Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title_short Influence of Blood Lead Concentration on the Nerve Conduction Velocity in Patients with End-Stage Renal Disease
title_sort influence of blood lead concentration on the nerve conduction velocity in patients with end-stage renal disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734006/
https://www.ncbi.nlm.nih.gov/pubmed/16614516
http://dx.doi.org/10.3346/jkms.2006.21.2.290
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