Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults

INTRODUCTION: Hereditary angioedema (HAE) is caused by mutations in the C1inh gene, leading to dysfunction of the C1-esterase inhibitor (C1-INH). C1-INH interacts with MASP-1 and MASP-2 proteases, participating in the mannan-binding lectin (MBL) pathway of complement activation. The aim of the study...

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Detalles Bibliográficos
Autores principales: Cedzyński, Maciej, Madaliński, Kazimierz, Gregorek, Hanna, Świerzko, Anna S., Nowicka, Ewa, Obtułowicz, Krystyna, Dzierżanowska-Fangrat, Katarzyna, Wojda, Urszula, Rabczenko, Daniel, Kawakami, Masaya
Formato: Texto
Lenguaje:English
Publicado: Birkhäuser-Verlag 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734250/
https://www.ncbi.nlm.nih.gov/pubmed/18250972
http://dx.doi.org/10.1007/s00005-008-0004-7

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