Cargando…

Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study

BACKGROUND: Studies have shown a clear relationship between depressive disorders and vitamin B12 deficiency. Gastroenteritis and Helicobacter pylori infections can cause vitamin B12 deficiency. Helicobacter pylori infections are not uncommon among people of Turkish descent in The Netherlands. AIM: T...

Descripción completa

Detalles Bibliográficos
Autores principales: Güzelcan, Yener, van Loon, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734346/
https://www.ncbi.nlm.nih.gov/pubmed/19674486
http://dx.doi.org/10.1186/1744-859X-8-18
_version_ 1782171147142430720
author Güzelcan, Yener
van Loon, Peter
author_facet Güzelcan, Yener
van Loon, Peter
author_sort Güzelcan, Yener
collection PubMed
description BACKGROUND: Studies have shown a clear relationship between depressive disorders and vitamin B12 deficiency. Gastroenteritis and Helicobacter pylori infections can cause vitamin B12 deficiency. Helicobacter pylori infections are not uncommon among people of Turkish descent in The Netherlands. AIM: To examine the frequency of vitamin B12 deficiency in depressive patients of Turkish descent and compare it to the frequency of vitamin B12 deficiency in depressive patients of Dutch descent. METHODS: The present study is a comparative cross-sectional study of 47 patients of Turkish descent and 28 of Dutch descent. The depressive disorder diagnosis and differential diagnosis were made using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition text revision (SCID). The severity of the depressive symptoms was determined using the Beck Depression Inventory (BDI) and the 21-item Hamilton Depression Rating Scale (HAM-D-21). Serum baseline vitamin B6 and B12, folic acid and total serum homocysteine (tHcy) levels were measured. RESULTS: The average ages of the patients of Turkish and Dutch descent were 40.57 and 44.75 years, respectively. There were no demonstrable differences between the serum vitamin B6, folic acid and tHcy levels in the two groups. The serum vitamin B12 levels were however clearly lower in the patients of Turkish descent than in those of Dutch descent. Vitamin B12 deficiency was however observed in 14 patients of Turkish descent and 1 of Dutch descent. This difference was significant. On the BDI, the patients of Turkish descent scored significantly higher than those of Dutch descent. Patients with vitamin B12 deficiency and those with hyperhomocysteinaemia had a significantly higher BDI score than patients with normal vitamin B12 and homocysteine levels. No relationship was observed with vitamin B12 and tHcy. CONCLUSION: Vitamin B12 deficiency occurs more frequently in depressive patients of Turkish than of Dutch descent. This is why it is advisable to test the vitamin B12 serum level in depressive patients of Turkish descent.
format Text
id pubmed-2734346
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27343462009-08-29 Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study Güzelcan, Yener van Loon, Peter Ann Gen Psychiatry Primary Research BACKGROUND: Studies have shown a clear relationship between depressive disorders and vitamin B12 deficiency. Gastroenteritis and Helicobacter pylori infections can cause vitamin B12 deficiency. Helicobacter pylori infections are not uncommon among people of Turkish descent in The Netherlands. AIM: To examine the frequency of vitamin B12 deficiency in depressive patients of Turkish descent and compare it to the frequency of vitamin B12 deficiency in depressive patients of Dutch descent. METHODS: The present study is a comparative cross-sectional study of 47 patients of Turkish descent and 28 of Dutch descent. The depressive disorder diagnosis and differential diagnosis were made using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition text revision (SCID). The severity of the depressive symptoms was determined using the Beck Depression Inventory (BDI) and the 21-item Hamilton Depression Rating Scale (HAM-D-21). Serum baseline vitamin B6 and B12, folic acid and total serum homocysteine (tHcy) levels were measured. RESULTS: The average ages of the patients of Turkish and Dutch descent were 40.57 and 44.75 years, respectively. There were no demonstrable differences between the serum vitamin B6, folic acid and tHcy levels in the two groups. The serum vitamin B12 levels were however clearly lower in the patients of Turkish descent than in those of Dutch descent. Vitamin B12 deficiency was however observed in 14 patients of Turkish descent and 1 of Dutch descent. This difference was significant. On the BDI, the patients of Turkish descent scored significantly higher than those of Dutch descent. Patients with vitamin B12 deficiency and those with hyperhomocysteinaemia had a significantly higher BDI score than patients with normal vitamin B12 and homocysteine levels. No relationship was observed with vitamin B12 and tHcy. CONCLUSION: Vitamin B12 deficiency occurs more frequently in depressive patients of Turkish than of Dutch descent. This is why it is advisable to test the vitamin B12 serum level in depressive patients of Turkish descent. BioMed Central 2009-08-13 /pmc/articles/PMC2734346/ /pubmed/19674486 http://dx.doi.org/10.1186/1744-859X-8-18 Text en Copyright © 2009 Güzelcan and van Loon; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Primary Research
Güzelcan, Yener
van Loon, Peter
Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title_full Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title_fullStr Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title_full_unstemmed Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title_short Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study
title_sort vitamin b12 status in patients of turkish and dutch descent with depression: a comparative cross-sectional study
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734346/
https://www.ncbi.nlm.nih.gov/pubmed/19674486
http://dx.doi.org/10.1186/1744-859X-8-18
work_keys_str_mv AT guzelcanyener vitaminb12statusinpatientsofturkishanddutchdescentwithdepressionacomparativecrosssectionalstudy
AT vanloonpeter vitaminb12statusinpatientsofturkishanddutchdescentwithdepressionacomparativecrosssectionalstudy