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In silico mutagenesis: a case study of the melanocortin 4 receptor

The melanocortin 4 receptor (MC4R) is a G-protein-coupled receptor (GPCR) and a key molecule in the regulation of energy homeostasis. At least 159 substitutions in the coding region of human MC4R (hMC4R) have been described experimentally; over 80 of those occur naturally, and many have been implica...

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Detalles Bibliográficos
Autores principales:	Bromberg, Yana, Overton, John, Vaisse, Christian, Leibel, Rudolph L., Rost, Burkhard
Formato:	Texto
Lenguaje:	English
Publicado:	The Federation of American Societies for Experimental Biology 2009
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735358/ https://www.ncbi.nlm.nih.gov/pubmed/19417090 http://dx.doi.org/10.1096/fj.08-127530

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