A customized and versatile high-density genotyping array for the mouse

We designed a high-density mouse genotyping array containing 623,124 SNPs that capture the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes that are targeted to functional elements and regions known to harbor segmental duplications. Th...

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Detalles Bibliográficos
Autores principales: Yang, Hyuna, Ding, Yueming, Hutchins, Lucie N, Szatkiewicz, Jin, Bell, Timothy A, Paigen, Beverly, Graber, Joel H, de Villena, Fernando Pardo-Manuel, AChurchill, Gary
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735580/
https://www.ncbi.nlm.nih.gov/pubmed/19668205
http://dx.doi.org/10.1038/nmeth.1359
Descripción
Sumario:We designed a high-density mouse genotyping array containing 623,124 SNPs that capture the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes that are targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy number variation, allele specific gene expression and DNA methylation and will extend the successes of human genome-wide association studies to the mouse.

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