A customized and versatile high-density genotyping array for the mouse

We designed a high-density mouse genotyping array containing 623,124 SNPs that capture the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes that are targeted to functional elements and regions known to harbor segmental duplications. Th...

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Detalles Bibliográficos
Autores principales: Yang, Hyuna, Ding, Yueming, Hutchins, Lucie N, Szatkiewicz, Jin, Bell, Timothy A, Paigen, Beverly, Graber, Joel H, de Villena, Fernando Pardo-Manuel, AChurchill, Gary
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735580/
https://www.ncbi.nlm.nih.gov/pubmed/19668205
http://dx.doi.org/10.1038/nmeth.1359
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author Yang, Hyuna
Ding, Yueming
Hutchins, Lucie N
Szatkiewicz, Jin
Bell, Timothy A
Paigen, Beverly
Graber, Joel H
de Villena, Fernando Pardo-Manuel
AChurchill, Gary
author_facet Yang, Hyuna
Ding, Yueming
Hutchins, Lucie N
Szatkiewicz, Jin
Bell, Timothy A
Paigen, Beverly
Graber, Joel H
de Villena, Fernando Pardo-Manuel
AChurchill, Gary
author_sort Yang, Hyuna
collection PubMed
description We designed a high-density mouse genotyping array containing 623,124 SNPs that capture the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes that are targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy number variation, allele specific gene expression and DNA methylation and will extend the successes of human genome-wide association studies to the mouse.
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spelling pubmed-27355802010-03-01 A customized and versatile high-density genotyping array for the mouse Yang, Hyuna Ding, Yueming Hutchins, Lucie N Szatkiewicz, Jin Bell, Timothy A Paigen, Beverly Graber, Joel H de Villena, Fernando Pardo-Manuel AChurchill, Gary Nat Methods Article We designed a high-density mouse genotyping array containing 623,124 SNPs that capture the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes that are targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy number variation, allele specific gene expression and DNA methylation and will extend the successes of human genome-wide association studies to the mouse. 2009-08-09 2009-09 /pmc/articles/PMC2735580/ /pubmed/19668205 http://dx.doi.org/10.1038/nmeth.1359 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Yang, Hyuna
Ding, Yueming
Hutchins, Lucie N
Szatkiewicz, Jin
Bell, Timothy A
Paigen, Beverly
Graber, Joel H
de Villena, Fernando Pardo-Manuel
AChurchill, Gary
A customized and versatile high-density genotyping array for the mouse
title A customized and versatile high-density genotyping array for the mouse
title_full A customized and versatile high-density genotyping array for the mouse
title_fullStr A customized and versatile high-density genotyping array for the mouse
title_full_unstemmed A customized and versatile high-density genotyping array for the mouse
title_short A customized and versatile high-density genotyping array for the mouse
title_sort customized and versatile high-density genotyping array for the mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735580/
https://www.ncbi.nlm.nih.gov/pubmed/19668205
http://dx.doi.org/10.1038/nmeth.1359
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