HI: haplotype improver using paired-end short reads

Summary: We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable. Availability: The executable and user manual...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Quan, MacArthur, Daniel, Ning, Zemin, Tyler-Smith, Chris
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735667/
https://www.ncbi.nlm.nih.gov/pubmed/19570807
http://dx.doi.org/10.1093/bioinformatics/btp412
_version_ 1782171271854817280
author Long, Quan
MacArthur, Daniel
Ning, Zemin
Tyler-Smith, Chris
author_facet Long, Quan
MacArthur, Daniel
Ning, Zemin
Tyler-Smith, Chris
author_sort Long, Quan
collection PubMed
description Summary: We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable. Availability: The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI. Contact: ql2@sanger.ac.uk
format Text
id pubmed-2735667
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-27356672009-09-02 HI: haplotype improver using paired-end short reads Long, Quan MacArthur, Daniel Ning, Zemin Tyler-Smith, Chris Bioinformatics Applications Note Summary: We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable. Availability: The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI. Contact: ql2@sanger.ac.uk Oxford University Press 2009-09-15 2009-07-01 /pmc/articles/PMC2735667/ /pubmed/19570807 http://dx.doi.org/10.1093/bioinformatics/btp412 Text en http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Note
Long, Quan
MacArthur, Daniel
Ning, Zemin
Tyler-Smith, Chris
HI: haplotype improver using paired-end short reads
title HI: haplotype improver using paired-end short reads
title_full HI: haplotype improver using paired-end short reads
title_fullStr HI: haplotype improver using paired-end short reads
title_full_unstemmed HI: haplotype improver using paired-end short reads
title_short HI: haplotype improver using paired-end short reads
title_sort hi: haplotype improver using paired-end short reads
topic Applications Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735667/
https://www.ncbi.nlm.nih.gov/pubmed/19570807
http://dx.doi.org/10.1093/bioinformatics/btp412
work_keys_str_mv AT longquan hihaplotypeimproverusingpairedendshortreads
AT macarthurdaniel hihaplotypeimproverusingpairedendshortreads
AT ningzemin hihaplotypeimproverusingpairedendshortreads
AT tylersmithchris hihaplotypeimproverusingpairedendshortreads

Ejemplares similares