Cargando…

Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition

BACKGROUND: Despite intensive effort, currently no effective anti-Ras therapies have successfully reached clinical application. Previous studies suggest that the histone deacetylatse (HDAC) inhibitor romidepsin, which is currently in clinical trials for the treatment of multiple malignancies, can bl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanker, Ariella B, Healy, Kevin D, Nichols, Jean, Der, Channing J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735739/ https://www.ncbi.nlm.nih.gov/pubmed/19682393 http://dx.doi.org/10.1186/1750-2187-4-5

Ejemplares similares

Transformation of NIH3T3 Cells with Synthetic c‐Ha‐ras Genes
por: Kamiya, Hiroyuki, et al.
Publicado: (1989)

Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells
por: Ronen, S M, et al.
Publicado: (2001)

c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts
Publicado: (1990)

Antimetastatic effect of epigenetic drugs, hydralazine and valproic acid, in Ras-transformed NIH 3T3 cells
por: Pérez-Cárdenas, Enrique, et al.
Publicado: (2018)

Restriction Enzyme Analysis of DNA Methylation in “Condensed” Chromatin of Ha-Ras-Transformed NIH 3T3 Cells
por: Mello, Maria Luiza S., et al.
Publicado: (2000)

Antimetastatic Effect of Epigenetic Drugs, Hydralazine and Valproic Acid, in Ras-Transformed NIH 3T3 Cells [Corrigendum]
Publicado: (2022)

Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells
Publicado: (1998)

Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells.
por: Liu, H. S., et al.
Publicado: (1998)

Induction of MAP kinase phosphatase 3 through Erk/MAP kinase activation in three oncogenic Ras (H-, K- and N-Ras)-expressing NIH/3T3 mouse embryonic fibroblast cell lines
por: Koo, JaeHyung, et al.
Publicado: (2016)

A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death
por: Pamonsinlapatham, Perayot, et al.
Publicado: (2008)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
por: Sheffels, Erin, et al.
Publicado: (2021)

Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.
por: Niimi, S., et al.
Publicado: (1991)

Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3
por: Ahn, Sung Yong, et al.
Publicado: (2017)

Inhibition of RAS in diabetic nephropathy
por: Yacoub, Rabi, et al.
Publicado: (2015)

Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains
por: Augsten, Martin, et al.
Publicado: (2014)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling
por: Shin, Wookjin, et al.
Publicado: (2018)

El policìa que rìe /
por: Sjowall, Maj y Per Wahloo 1935-
Publicado: (2016)

Si ríe el emperador /
por: Bracho, Coral
Publicado: (2010)

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
por: Ilter, Metehan, et al.
Publicado: (2022)

Doped or Quantum-Dot Layers as In Situ Etch-Stop Indicators for III/V Semiconductor Reactive Ion Etching (RIE) Using Reflectance Anisotropy Spectroscopy (RAS)
por: Sombrio, Guilherme, et al.
Publicado: (2021)

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
Publicado: (1995)

The Expression of Tumor Rejection Antigen on Rat Fetus Fibroblasts Transformed by the ras Oncogene
por: Okubo, Mamoru, et al.
Publicado: (1988)

Syndecan-1 is up-regulated in ras-transformed intestinal epithelial cells.
por: Wong, Z. M., et al.
Publicado: (1998)

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling
por: Yelland, Tamas, et al.
Publicado: (2022)

Transforming ras oncogenes and multistage carcinogenesis.
por: Balmain, A.
Publicado: (1985)

¿Por qué ríe la gente? /
por: Rabell, Malkah
Publicado: (1967)

Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors
por: Menachem, A, et al.
Publicado: (2015)

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells
por: Liu, Zhao, et al.
Publicado: (2016)

Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts
por: Gaglio, Daniela, et al.
Publicado: (2009)

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target
por: Hong, Sung-Jun, et al.
Publicado: (2020)

Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP kinase phosphatase 3 (MKP3) in NIH3T3 cells
por: Park, Young Jae, et al.
Publicado: (2014)

Heterogeneity of the NIH3T3 Fibroblast Cell Line
por: Rahimi, Amir Mohammad, et al.
Publicado: (2022)

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
por: Casar, Berta, et al.
Publicado: (2018)

Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells
por: Yamasaki, Masao, et al.
Publicado: (2012)

Dynamic regulation of RAS and RAS signaling
por: Kolch, Walter, et al.
Publicado: (2023)

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts
por: Pelletier, Joffrey, et al.
Publicado: (2015)

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer
por: Pfohl, Ulrike, et al.
Publicado: (2022)

The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells
por: Takino, Jun-ichi, et al.
Publicado: (2019)

Superoxide Inhibits Guanine Nucleotide Exchange Factor (GEF) Action on Ras, but not on Rho, through Desensitization of Ras to GEF
por: Wey, Michael, et al.
Publicado: (2014)

Mulberry polyphenol extracts attenuated senescence through inhibition of Ras/ERK via promoting Ras degradation in VSMC
por: Chen, Ching-Pei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iesvkv25vnudf2n2p4fgfma927