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The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers
ATCA (2-amino-2-thiazoline-4-carboxylic acid) is a promising marker to assess cyanide exposure because of several advantages of ATCA analysis over direct determination of cyanide and alternative cyanide biomarkers (i.e. stability in biological matrices, consistent recovery, and relatively small endo...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736539/ https://www.ncbi.nlm.nih.gov/pubmed/19730703 http://dx.doi.org/10.1080/15376510802488165 |
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author | Logue, Brian A. Maserek, Wendy K. Rockwood, Gary A. Keebaugh, Michael W. Baskin, Steven I. |
author_facet | Logue, Brian A. Maserek, Wendy K. Rockwood, Gary A. Keebaugh, Michael W. Baskin, Steven I. |
author_sort | Logue, Brian A. |
collection | PubMed |
description | ATCA (2-amino-2-thiazoline-4-carboxylic acid) is a promising marker to assess cyanide exposure because of several advantages of ATCA analysis over direct determination of cyanide and alternative cyanide biomarkers (i.e. stability in biological matrices, consistent recovery, and relatively small endogenous concentrations). Concentrations of ATCA in the plasma of smoking and non-smoking human volunteers were analyzed using gas-chromatography mass-spectrometry to establish the feasibility of using ATCA as a marker for cyanide exposure. The levels of ATCA in plasma of smoking volunteers, 17.2 ng/ml, were found to be significantly (p < 0.001) higher than that of non-smoking volunteers, 11.8 ng/ml. Comparison of ATCA concentrations of smokers relative to non-smokers in both urine and plasma yielded relatively similar results. The concentration ratio of ATCA for smokers versus non-smokers in plasma and urine was compared to similar literature studies of cyanide and thiocyanate, and correlations are discussed. This study supports previous evidence that ATCA can be used to determine past cyanide exposure and indicates that further studies should be pursued to validate the use of ATCA as a marker of cyanide exposure. |
format | Text |
id | pubmed-2736539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-27365392009-09-02 The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers Logue, Brian A. Maserek, Wendy K. Rockwood, Gary A. Keebaugh, Michael W. Baskin, Steven I. Toxicol Mech Methods Research Article ATCA (2-amino-2-thiazoline-4-carboxylic acid) is a promising marker to assess cyanide exposure because of several advantages of ATCA analysis over direct determination of cyanide and alternative cyanide biomarkers (i.e. stability in biological matrices, consistent recovery, and relatively small endogenous concentrations). Concentrations of ATCA in the plasma of smoking and non-smoking human volunteers were analyzed using gas-chromatography mass-spectrometry to establish the feasibility of using ATCA as a marker for cyanide exposure. The levels of ATCA in plasma of smoking volunteers, 17.2 ng/ml, were found to be significantly (p < 0.001) higher than that of non-smoking volunteers, 11.8 ng/ml. Comparison of ATCA concentrations of smokers relative to non-smokers in both urine and plasma yielded relatively similar results. The concentration ratio of ATCA for smokers versus non-smokers in plasma and urine was compared to similar literature studies of cyanide and thiocyanate, and correlations are discussed. This study supports previous evidence that ATCA can be used to determine past cyanide exposure and indicates that further studies should be pursued to validate the use of ATCA as a marker of cyanide exposure. Informa Healthcare 2009-06-30 2009-03 /pmc/articles/PMC2736539/ /pubmed/19730703 http://dx.doi.org/10.1080/15376510802488165 Text en © 2009 Informa UK Ltd http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Logue, Brian A. Maserek, Wendy K. Rockwood, Gary A. Keebaugh, Michael W. Baskin, Steven I. The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title | The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title_full | The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title_fullStr | The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title_full_unstemmed | The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title_short | The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
title_sort | analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736539/ https://www.ncbi.nlm.nih.gov/pubmed/19730703 http://dx.doi.org/10.1080/15376510802488165 |
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