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Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons

The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth, proliferation and cell survival. Pten deleti...

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Detalles Bibliográficos
Autores principales:	Diaz-Ruiz, Oscar, Zapata, Agustin, Shan, Lufei, Zhang, YaJun, Tomac, Andreas C., Malik, Nasir, de la Cruz, Fidel, Bäckman, Cristina M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736587/ https://www.ncbi.nlm.nih.gov/pubmed/19750226 http://dx.doi.org/10.1371/journal.pone.0007027

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