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ARLTS1 polymorphisms and basal cell carcinoma of the skin
Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study the role of ARLTS1 polymorphic variations in basal cell carcinoma of the skin (BCC). In a...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736660/ https://www.ncbi.nlm.nih.gov/pubmed/19723348 http://dx.doi.org/10.1186/1897-4287-5-1-25 |
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author | Li, Xuchen Gast, Andreas Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Hemminki, Kari Kumar, Rajiv |
author_facet | Li, Xuchen Gast, Andreas Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Hemminki, Kari Kumar, Rajiv |
author_sort | Li, Xuchen |
collection | PubMed |
description | Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study the role of ARLTS1 polymorphic variations in basal cell carcinoma of the skin (BCC). In a case-control study, 529 cases diagnosed with BCC and 533 controls from Hungary, Romania and Slovakia were genotyped for the S99S (297G>A), P131L (392C>T), L132L (396G>C), C148R (442T>C) and W149X (446G>A) polymorphisms in the ARLTS1 gene. No significant association between any of the single nucleotide polymorphisms (SNP) and risk of BCC (S99S, odds ratio (OR) 0.96, 95% confidence interval (CI) 0.60-1.53; P131L, OR 1.31 95%CI 0.74-2.31; L132L, OR 0.50, 95%CI 0.02-7.07; C148R, OR 0.50, 95%CI 0.69-1.18; and W149X, OR 1.01, 95%CI 0.37-2.79) was detected. Furthermore, no significant difference in the distribution of haplotypes due to five polymorphisms in the ARLTS1 gene was found between the BCC cases and controls. Our data rule out an association between variants in ARLTS1 and risk of BCC in the investigated population. |
format | Text |
id | pubmed-2736660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27366602009-09-03 ARLTS1 polymorphisms and basal cell carcinoma of the skin Li, Xuchen Gast, Andreas Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Hemminki, Kari Kumar, Rajiv Hered Cancer Clin Pract Research Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study the role of ARLTS1 polymorphic variations in basal cell carcinoma of the skin (BCC). In a case-control study, 529 cases diagnosed with BCC and 533 controls from Hungary, Romania and Slovakia were genotyped for the S99S (297G>A), P131L (392C>T), L132L (396G>C), C148R (442T>C) and W149X (446G>A) polymorphisms in the ARLTS1 gene. No significant association between any of the single nucleotide polymorphisms (SNP) and risk of BCC (S99S, odds ratio (OR) 0.96, 95% confidence interval (CI) 0.60-1.53; P131L, OR 1.31 95%CI 0.74-2.31; L132L, OR 0.50, 95%CI 0.02-7.07; C148R, OR 0.50, 95%CI 0.69-1.18; and W149X, OR 1.01, 95%CI 0.37-2.79) was detected. Furthermore, no significant difference in the distribution of haplotypes due to five polymorphisms in the ARLTS1 gene was found between the BCC cases and controls. Our data rule out an association between variants in ARLTS1 and risk of BCC in the investigated population. BioMed Central 2007-03-15 /pmc/articles/PMC2736660/ /pubmed/19723348 http://dx.doi.org/10.1186/1897-4287-5-1-25 Text en |
spellingShingle | Research Li, Xuchen Gast, Andreas Rudnai, Peter Gurzau, Eugene Koppova, Kvetoslava Hemminki, Kari Kumar, Rajiv ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title | ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title_full | ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title_fullStr | ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title_full_unstemmed | ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title_short | ARLTS1 polymorphisms and basal cell carcinoma of the skin |
title_sort | arlts1 polymorphisms and basal cell carcinoma of the skin |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736660/ https://www.ncbi.nlm.nih.gov/pubmed/19723348 http://dx.doi.org/10.1186/1897-4287-5-1-25 |
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