Prion variants, species barriers, generation and propagation

Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants.

Detalles Bibliográficos
Autores principales: Wickner, Reed B, Edskes, Herman K, Shewmaker, Frank, Kryndushkin, Dmitry, Nemecek, Julie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736662/
https://www.ncbi.nlm.nih.gov/pubmed/19519931
http://dx.doi.org/10.1186/jbiol148
Descripción
Sumario:Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants.

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