Prion variants, species barriers, generation and propagation

Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants.

Detalles Bibliográficos
Autores principales: Wickner, Reed B, Edskes, Herman K, Shewmaker, Frank, Kryndushkin, Dmitry, Nemecek, Julie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736662/
https://www.ncbi.nlm.nih.gov/pubmed/19519931
http://dx.doi.org/10.1186/jbiol148
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author Wickner, Reed B
Edskes, Herman K
Shewmaker, Frank
Kryndushkin, Dmitry
Nemecek, Julie
author_facet Wickner, Reed B
Edskes, Herman K
Shewmaker, Frank
Kryndushkin, Dmitry
Nemecek, Julie
author_sort Wickner, Reed B
collection PubMed
description Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants.
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spelling pubmed-27366622009-11-26 Prion variants, species barriers, generation and propagation Wickner, Reed B Edskes, Herman K Shewmaker, Frank Kryndushkin, Dmitry Nemecek, Julie J Biol Minireview Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants. BioMed Central 2009 2009-05-26 /pmc/articles/PMC2736662/ /pubmed/19519931 http://dx.doi.org/10.1186/jbiol148 Text en Copyright © 2009 BioMed Central Ltd
spellingShingle Minireview
Wickner, Reed B
Edskes, Herman K
Shewmaker, Frank
Kryndushkin, Dmitry
Nemecek, Julie
Prion variants, species barriers, generation and propagation
title Prion variants, species barriers, generation and propagation
title_full Prion variants, species barriers, generation and propagation
title_fullStr Prion variants, species barriers, generation and propagation
title_full_unstemmed Prion variants, species barriers, generation and propagation
title_short Prion variants, species barriers, generation and propagation
title_sort prion variants, species barriers, generation and propagation
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736662/
https://www.ncbi.nlm.nih.gov/pubmed/19519931
http://dx.doi.org/10.1186/jbiol148
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AT shewmakerfrank prionvariantsspeciesbarriersgenerationandpropagation
AT kryndushkindmitry prionvariantsspeciesbarriersgenerationandpropagation
AT nemecekjulie prionvariantsspeciesbarriersgenerationandpropagation

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