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Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system
The aryl hydrocarbon receptor is a ligand-activated transcriptional regulator that binds dioxin and other exogenous contaminants and is responsible for their toxic effects, including immunosuppression. New evidence suggests, however, that the aryl hydrocarbon receptor has a physiological role in the...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736674/ https://www.ncbi.nlm.nih.gov/pubmed/19691822 http://dx.doi.org/10.1186/jbiol170 |
| _version_ | 1782171358405328896 |
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| author | Stockinger, Brigitta |
| author_facet | Stockinger, Brigitta |
| author_sort | Stockinger, Brigitta |
| collection | PubMed |
| description | The aryl hydrocarbon receptor is a ligand-activated transcriptional regulator that binds dioxin and other exogenous contaminants and is responsible for their toxic effects, including immunosuppression. New evidence suggests, however, that the aryl hydrocarbon receptor has a physiological role in the immune system, and the immunosuppressive effects of dioxin may reflect a more subtle disruption of the regulatory interactions between immune cells. |
| format | Text |
| id | pubmed-2736674 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27366742010-02-17 Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system Stockinger, Brigitta J Biol Opinion The aryl hydrocarbon receptor is a ligand-activated transcriptional regulator that binds dioxin and other exogenous contaminants and is responsible for their toxic effects, including immunosuppression. New evidence suggests, however, that the aryl hydrocarbon receptor has a physiological role in the immune system, and the immunosuppressive effects of dioxin may reflect a more subtle disruption of the regulatory interactions between immune cells. BioMed Central 2009 2009-08-17 /pmc/articles/PMC2736674/ /pubmed/19691822 http://dx.doi.org/10.1186/jbiol170 Text en Copyright © 2009 BioMed Central Ltd |
| spellingShingle | Opinion Stockinger, Brigitta Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title | Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title_full | Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title_fullStr | Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title_full_unstemmed | Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title_short | Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| title_sort | beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system |
| topic | Opinion |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736674/ https://www.ncbi.nlm.nih.gov/pubmed/19691822 http://dx.doi.org/10.1186/jbiol170 |
| work_keys_str_mv | AT stockingerbrigitta beyondtoxicityarylhydrocarbonreceptormediatedfunctionsintheimmunesystem |