Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

BACKGROUND: Juvenile pilocytic astrocytomas (JPA), a subgroup of low-grade astrocytomas (LGA), are common, heterogeneous and poorly understood subset of brain tumours in children. Chromosomal 7q34 duplication leading to fusion genes formed between KIAA1549 and BRAF and subsequent constitutive activa...

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Detalles Bibliográficos
Autores principales: Jacob, K, Albrecht, S, Sollier, C, Faury, D, Sader, E, Montpetit, A, Serre, D, Hauser, P, Garami, M, Bognar, L, Hanzely, Z, Montes, J L, Atkinson, J, Farmer, J-P, Bouffet, E, Hawkins, C, Tabori, U, Jabado, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736806/
https://www.ncbi.nlm.nih.gov/pubmed/19603027
http://dx.doi.org/10.1038/sj.bjc.6605179

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