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Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies

BACKGROUND: Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to suppress focus formation of RhoA transformed NIH3T3 cells. METHODS: Sixty-four novel structural analogues of Y27632 were s...

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Detalles Bibliográficos
Autores principales:	Hampson, L, He, X T, Oliver, A W, Hadfield, J A, Kemp, T, Butler, J, McGown, A, Kitchener, H C, Hampson, I N
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736836/ https://www.ncbi.nlm.nih.gov/pubmed/19707205 http://dx.doi.org/10.1038/sj.bjc.6605208

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