CHEK2 1100 delC mutation in Russian ovarian cancer patients

BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cance...

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Autores principales: Krylova, Nadezhda Yu, Ponomariova, Daria N, Sherina, Natalia Yu, Ogorodnikova, Natalia Yu, Logvinov, Denis A, Porhanova, Natalia V, Lobeiko, Oksana S, Urmancheyeva, Adel F, Maximov, Sergey Ya, Togo, Alexandr V, Suspitsin, Evgeny N, Imyanitov, Evgeny N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736987/
https://www.ncbi.nlm.nih.gov/pubmed/19725991
http://dx.doi.org/10.1186/1897-4287-5-3-153
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author Krylova, Nadezhda Yu
Ponomariova, Daria N
Sherina, Natalia Yu
Ogorodnikova, Natalia Yu
Logvinov, Denis A
Porhanova, Natalia V
Lobeiko, Oksana S
Urmancheyeva, Adel F
Maximov, Sergey Ya
Togo, Alexandr V
Suspitsin, Evgeny N
Imyanitov, Evgeny N
author_facet Krylova, Nadezhda Yu
Ponomariova, Daria N
Sherina, Natalia Yu
Ogorodnikova, Natalia Yu
Logvinov, Denis A
Porhanova, Natalia V
Lobeiko, Oksana S
Urmancheyeva, Adel F
Maximov, Sergey Ya
Togo, Alexandr V
Suspitsin, Evgeny N
Imyanitov, Evgeny N
author_sort Krylova, Nadezhda Yu
collection PubMed
description BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers.
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spelling pubmed-27369872009-09-03 CHEK2 1100 delC mutation in Russian ovarian cancer patients Krylova, Nadezhda Yu Ponomariova, Daria N Sherina, Natalia Yu Ogorodnikova, Natalia Yu Logvinov, Denis A Porhanova, Natalia V Lobeiko, Oksana S Urmancheyeva, Adel F Maximov, Sergey Ya Togo, Alexandr V Suspitsin, Evgeny N Imyanitov, Evgeny N Hered Cancer Clin Pract Research BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers. BioMed Central 2007-09-15 /pmc/articles/PMC2736987/ /pubmed/19725991 http://dx.doi.org/10.1186/1897-4287-5-3-153 Text en
spellingShingle Research
Krylova, Nadezhda Yu
Ponomariova, Daria N
Sherina, Natalia Yu
Ogorodnikova, Natalia Yu
Logvinov, Denis A
Porhanova, Natalia V
Lobeiko, Oksana S
Urmancheyeva, Adel F
Maximov, Sergey Ya
Togo, Alexandr V
Suspitsin, Evgeny N
Imyanitov, Evgeny N
CHEK2 1100 delC mutation in Russian ovarian cancer patients
title CHEK2 1100 delC mutation in Russian ovarian cancer patients
title_full CHEK2 1100 delC mutation in Russian ovarian cancer patients
title_fullStr CHEK2 1100 delC mutation in Russian ovarian cancer patients
title_full_unstemmed CHEK2 1100 delC mutation in Russian ovarian cancer patients
title_short CHEK2 1100 delC mutation in Russian ovarian cancer patients
title_sort chek2 1100 delc mutation in russian ovarian cancer patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736987/
https://www.ncbi.nlm.nih.gov/pubmed/19725991
http://dx.doi.org/10.1186/1897-4287-5-3-153
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