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Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations
BACKGROUND: Bisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly in humans may cause endocrine disruption. Whether ingestion of food or beverages from polycarbonate containers increas...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737011/ https://www.ncbi.nlm.nih.gov/pubmed/19750099 http://dx.doi.org/10.1289/ehp.0900604 |
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author | Carwile, Jenny L. Luu, Henry T. Bassett, Laura S. Driscoll, Daniel A. Yuan, Caterina Chang, Jennifer Y. Ye, Xiaoyun Calafat, Antonia M. Michels, Karin B. |
author_facet | Carwile, Jenny L. Luu, Henry T. Bassett, Laura S. Driscoll, Daniel A. Yuan, Caterina Chang, Jennifer Y. Ye, Xiaoyun Calafat, Antonia M. Michels, Karin B. |
author_sort | Carwile, Jenny L. |
collection | PubMed |
description | BACKGROUND: Bisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly in humans may cause endocrine disruption. Whether ingestion of food or beverages from polycarbonate containers increases BPA concentrations in humans has not been studied. OBJECTIVES: We examined the association between use of polycarbonate beverage containers and urinary BPA concentrations in humans. METHODS: We conducted a nonrandomized intervention of 77 Harvard College students to compare urinary BPA concentrations collected after a washout phase of 1 week to those taken after an intervention week during which most cold beverages were consumed from polycarbonate drinking bottles. Paired t-tests were used to assess the difference in urinary BPA concentrations before and after polycarbonate bottle use. RESULTS: The geometric mean urinary BPA concentration at the end of the washout phase was 1.2 μg/g creatinine, increasing to 2.0 μg/g creatinine after 1 week of polycarbonate bottle use. Urinary BPA concentrations increased by 69% after use of polycarbonate bottles (p < 0.0001). The association was stronger among participants who reported ≥ 90% compliance (77% increase; p < 0.0001) than among those reporting < 90% compliance (55% increase; p = 0.03), but this difference was not statistically significant (p = 0.54). CONCLUSIONS: One week of polycarbonate bottle use increased urinary BPA concentrations by two-thirds. Regular consumption of cold beverages from polycarbonate bottles is associated with a substantial increase in urinary BPA concentrations irrespective of exposure to BPA from other sources. |
format | Text |
id | pubmed-2737011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27370112009-09-11 Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations Carwile, Jenny L. Luu, Henry T. Bassett, Laura S. Driscoll, Daniel A. Yuan, Caterina Chang, Jennifer Y. Ye, Xiaoyun Calafat, Antonia M. Michels, Karin B. Environ Health Perspect Research BACKGROUND: Bisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly in humans may cause endocrine disruption. Whether ingestion of food or beverages from polycarbonate containers increases BPA concentrations in humans has not been studied. OBJECTIVES: We examined the association between use of polycarbonate beverage containers and urinary BPA concentrations in humans. METHODS: We conducted a nonrandomized intervention of 77 Harvard College students to compare urinary BPA concentrations collected after a washout phase of 1 week to those taken after an intervention week during which most cold beverages were consumed from polycarbonate drinking bottles. Paired t-tests were used to assess the difference in urinary BPA concentrations before and after polycarbonate bottle use. RESULTS: The geometric mean urinary BPA concentration at the end of the washout phase was 1.2 μg/g creatinine, increasing to 2.0 μg/g creatinine after 1 week of polycarbonate bottle use. Urinary BPA concentrations increased by 69% after use of polycarbonate bottles (p < 0.0001). The association was stronger among participants who reported ≥ 90% compliance (77% increase; p < 0.0001) than among those reporting < 90% compliance (55% increase; p = 0.03), but this difference was not statistically significant (p = 0.54). CONCLUSIONS: One week of polycarbonate bottle use increased urinary BPA concentrations by two-thirds. Regular consumption of cold beverages from polycarbonate bottles is associated with a substantial increase in urinary BPA concentrations irrespective of exposure to BPA from other sources. National Institute of Environmental Health Sciences 2009-09 2009-05-12 /pmc/articles/PMC2737011/ /pubmed/19750099 http://dx.doi.org/10.1289/ehp.0900604 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Carwile, Jenny L. Luu, Henry T. Bassett, Laura S. Driscoll, Daniel A. Yuan, Caterina Chang, Jennifer Y. Ye, Xiaoyun Calafat, Antonia M. Michels, Karin B. Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title | Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title_full | Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title_fullStr | Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title_full_unstemmed | Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title_short | Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations |
title_sort | polycarbonate bottle use and urinary bisphenol a concentrations |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737011/ https://www.ncbi.nlm.nih.gov/pubmed/19750099 http://dx.doi.org/10.1289/ehp.0900604 |
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